Self-assembling peptide hydrogels facilitate vascularization in two-component scaffolds

Siddiqui, Zain; Sarkar, Biplab; Kim, Ka Kyung; Kumar, Arjun; Paul, Reshma; Mahajan, Aryan; Grasman, Jonathan M.; Yang, Jian; Kumar, Vivek

doi:10.1016/j.cej.2021.130145

Cited by 26 publications

(28 citation statements)

References 60 publications

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“…[56] Carrejo et al evaluated K2 as a diabetic wound dressing and observed the greatest depth of granulation tissue complimented by degradation of SAPH and a high cellular density throughout the wound bed. [57] Additionally, SLan showed promoted angiogenesis demonstrated both in vitro and vivo models, [58] and confirm the correct mass and purity with LC/MS techniques (Figure S1, Supporting Information) as well as the localization of the hydrogel SLan to the wound bed (Figure S2, Supporting Information). As one of the previous studies showed efficacy of SLan in dental pulp regeneration in canines, [54] here it was focused on application of this proangiogenic hydrogel in diabetic wound healing.…”

Section: Resultsmentioning

confidence: 53%

Angiogenic Hydrogels to Accelerate Early Wound Healing

Kim

Siddiqui

Acevedo‐Jake

et al. 2022

Macromolecular Bioscience

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Diabetes mellitus affects an increasing proportion of the population, and is projected to double by 2060. Comorbidities contribute to an interrupted healing process which is delayed, prolonged, and associated with increased susceptibility to infection and unresolved inflammation. This leads to chronic nonhealing wounds and potential amputation. Here, the use of a bioactive angiogenic peptide‐based hydrogel, SLan, is examined to improve early wound healing in diabetic rats, and its performance is compared to clinically utilized biosynthetic peptide‐based materials such as Puramatrix. Streptozotocin‐treated diabetic rats underwent 8 mm biopsy wounding in their dorsum. Wounds are treated with either Low (1 w%) SLan, High (4 w%) SLan, phosphate buffered saline (PBS), Puramatrix, or K2 (an unfunctionalized nonbioactive control sequentially similar to SLan), covered with Tegaderm, and monitored on for a month; animals are sacrificed for histomorphic analyses and immunostaining. Pharmacokinetic analysis showing no trafficking of peptides from the wound into the circulation. SLan groups show similar wound contraction as control groups (Puramatrix, PBS, and K2), however, showing marked improvement in healing in earlier time points, including increased deposition of new mature blood vessels. Altogether the results suggest this material can be used to “jumpstart” the diabetic wound healing process.

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Section: Resultsmentioning

confidence: 53%

Angiogenic Hydrogels to Accelerate Early Wound Healing

Kim

Siddiqui

Acevedo‐Jake

et al. 2022

Macromolecular Bioscience

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“…Interestingly, the emergence of functional hydrogels provides plenty of possibilities to endow 3D printed scaffolds with hydrophilic network analogous to ECM [ [8] , [9] , [10] ]. Hydrogels demonstrate processability [ 11 ], and more remarkably, can be designed to adjust the key factors modulating bone regeneration, including growth factor delivery, mechanical stimulation, and cell-to-cell communication [ [12] , [13] , [14] , [15] , [16] , [17] , [18] ]. However, the properties of conventional chemical-crosslinking hydrogels are generally static, while cells within a tissue are subjected to dynamic micro-environment that determines their function and immunogenicity, variable physicochemical properties and fate [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Black phosphorus nanosheets-enabled DNA hydrogel integrating 3D-printed scaffold for promoting vascularized bone regeneration

Miao

Chen

Luo

et al. 2023

Bioactive Materials

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“…Polymeric hydrogels are attractive tissue repair materials ( Kurian et al, 2022 ). Biological scaffold materials constructed from hydrogels can interact with surrounding tissues, modulate the activity of cells and growth factors, and induce osteogenesis and angiogenesis ( Siddiqui et al, 2021 ). Recently, Zhao and his co-workers prepared a hybrid nanoparticle (CMCh-ACP) by mixing carboxymethyl chitosan (CMCh) and amorphous calcium phosphate (ACP) and doping glucono d -lactone (GDL) into it by alkaline hydration.…”

Section: Bone-targeted Strategiesmentioning

confidence: 99%

Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease

Chen

et al. 2022

Front. Pharmacol.

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Targeted delivery by either systemic or local targeting of therapeutics to the bone is an attractive treatment for various bone metabolism diseases such as osteoporosis, osteoarthritis, osteosarcoma, osteomyelitis, etc. To overcome the limitations of direct drug delivery, the combination of bone-targeted agents with nanotechnology has the opportunity to provide a more effective therapeutic approach, where engineered nanoparticles cause the drug to accumulate in the bone, thereby improving efficacy and minimizing side effects. Here, we summarize the current advances in systemic or local bone-targeting approaches and nanosystem applications in bone diseases, which may provide new insights into nanocarrier-delivered drugs for the targeted treatment of bone diseases. We envision that novel drug delivery carriers developed based on nanotechnology will be a potential vehicle for the treatment of currently incurable bone diseases and are expected to be translated into clinical applications.

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Self-assembling peptide hydrogels facilitate vascularization in two-component scaffolds

Cited by 26 publications

References 60 publications

Angiogenic Hydrogels to Accelerate Early Wound Healing

Angiogenic Hydrogels to Accelerate Early Wound Healing

Black phosphorus nanosheets-enabled DNA hydrogel integrating 3D-printed scaffold for promoting vascularized bone regeneration

Bone-Targeted Nanoparticle Drug Delivery System: An Emerging Strategy for Bone-Related Disease

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