Self-assembling peptides as immunomodulatory biomaterials

Hernández, Andrea; Hartgerink, Jeffrey D.; Young, Simon

doi:10.3389/fbioe.2023.1139782

Cited by 13 publications

(4 citation statements)

References 137 publications

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“…The use of injectable, self-assembling peptide scaffold hydrogels for the prolonged and controlled release of human antibodies offers a targeted approach to drug delivery for oral cancer therapy [ 92 ]. These self-assembling peptide hydrogels have been extensively studied for their potential for 3D scaffold-based drug delivery systems, providing a versatile and efficient platform for localized drug release.…”

Section: Different Types Of Scaffold-based Drug Delivery In Oral Canc...mentioning

confidence: 99%

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Saberian,

Jenča,

Petrášová

et al. 2024

Pharmaceutics

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This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin and paclitaxel, have proven effective in inhibiting oral cancer cell proliferation, establishing a promising avenue for site-specific drug delivery. The application of synthetic scaffolds, including Poly Ethylene Glycol (PEG) and poly(lactic-co-glycolic acid) (PLGA), and natural materials, like collagen or silk, in 3D systems has been pivotal for controlled release of therapeutic agents, executing diverse anti-cancer strategies. A key advancement in this field is the advent of smart scaffolds designed for sequential cancer therapy, which strive to refine drug delivery systems, minimizing surgical interventions, accentuating the significance of 3D scaffolds in oral cancer management. These systems, encompassing local drug-coated scaffolds and other scaffold-based platforms, hold the potential to transform oral cancer treatment through precise interventions, yielding improved patient outcomes. Local drug delivery via scaffolds can mitigate systemic side effects typically associated with chemotherapy, such as nausea, alopecia, infections, and gastrointestinal issues. Post-drug release, scaffolds foster a conducive environment for non-cancerous cell growth, adhering and proliferation, demonstrating restorative potential. Strategies for controlled and targeted drug delivery in oral cancer therapy span injectable self-assembling peptide hydrogels, nanocarriers, and dual drug-loaded nanofibrous scaffolds. These systems ensure prolonged release, synergistic effects, and tunable targeting, enhancing drug delivery efficiency while reducing systemic exposure. Smart scaffolds, capable of sequential drug release, transitioning to cell-friendly surfaces, and enabling combinatorial therapy, hold the promise to revolutionize treatment by delivering precise interventions and optimized outcomes. In essence, scaffold-based drug delivery systems, through their varied forms and functionalities, are reshaping oral cancer therapy. They target drug delivery efficiency, diminish side effects, and present avenues for personalization. Challenges like fabrication intricacy, biocompatibility, and scalability call for additional research. Nonetheless, the perspective on scaffold-based systems in oral cancer treatment is optimistic, as ongoing advancements aim to surmount current limitations and fully leverage their potential in cancer therapy.

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Section: Different Types Of Scaffold-based Drug Delivery In Oral Canc...mentioning

confidence: 99%

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Saberian,

Jenča,

Petrášová

et al. 2024

Pharmaceutics

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“…Self-assembling peptides (SAPs) are designer biomaterials readily available from naturally occurring amino acids that instinctively form cross-linked nanofibers, and are transformed into nanoscale hydrogels. 77,78 Liu et al . 37 reported the hepatocyte growth factor (HGF) and the TNF-α neutralizing antibody (anti-TNF-α) co-delivered using an injectable, self-assembling peptide/heparin (SAP/Hep) hydrogel (Fig.…”

Section: Drug Delivery Strategies For Renal Antifibrosismentioning

confidence: 99%

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Huang,

Lu,

Chen

et al. 2024

J. Mater. Chem. B

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“…Gelain and co-workers reported an in vivo study of biomimetic electrospun SAP micro-channels suitable to support NSC transplant in spinal cord injury [121]. Important results in the field of SAPs as biomaterials are emerging for cancer therapy [122,123], as immunomodulatory agents [124], and against antibiotic resistance [125], as well as for tissue regeneration, drug delivery [126], sensing [127,128], 3D printing [129], and nanomedicine [130][131][132]. protofilaments of microtubule assemble playing fundamental roles in eukaryotic cells [134,135].…”

Section: Self-assembling Peptidesmentioning

confidence: 99%

Recent Advances in the Development of Biomimetic Materials

Ciulla,

Massironi,

Sugni

et al. 2023

Gels

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In this review, we focused on recent efforts in the design and development of materials with biomimetic properties. Innovative methods promise to emulate cell microenvironments and tissue functions, but many aspects regarding cellular communication, motility, and responsiveness remain to be explained. We photographed the state-of-the-art advancements in biomimetics, and discussed the complexity of a “bottom-up” artificial construction of living systems, with particular highlights on hydrogels, collagen-based composites, surface modifications, and three-dimensional (3D) bioprinting applications. Fast-paced 3D printing and artificial intelligence, nevertheless, collide with reality: How difficult can it be to build reproducible biomimetic materials at a real scale in line with the complexity of living systems? Nowadays, science is in urgent need of bioengineering technologies for the practical use of bioinspired and biomimetics for medicine and clinics.

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Self-assembling peptides as immunomodulatory biomaterials

Cited by 13 publications

References 137 publications

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach

Advances in drug delivery-based therapeutic strategies for renal fibrosis treatment

Recent Advances in the Development of Biomimetic Materials

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