Self-assembling polysaccharide systems based on cyclodextrin complexation: Synthesis, properties and potential applications in the biomaterials field

Abstract

The supramolecular assemblies based on polysaccharides modified by cyclodextrins (CDs) and/or hydrophobic guest molecules have inspired interesting developments in the biomedical, pharmaceutical and cosmetic fields. This review will update the recent progress in the design, synthesis and study of such supramolecular structures. Preliminary studies demonstrated that such systems, based on the physical cross-linking of biopolymers through CD inclusion complexation, have potential as injectable hydrogels for the controlled release of drugs. Their nanoscale association also lead to the formation of original particles and films which pave the way to new applications in drug delivery and tissue engineering.

The impact of biochar on the bioaccessibility of14C-phenanthrene in aged soil

“…For instance, Rhodes et al 37 showed good linear correlations between amounts of 14 C-phenanthrene mineralised and amounts extracted in control soils (0%) (r 2 ¼ 0.864; slope ¼ 0.89; intercept ¼ 5.74) and 0.1% (r 2 ¼ 0.67; slope ¼ 0.95; intercept ¼ 20.1) AC amended soils. 69,70,72 Prior to extraction, 14 C-phenanthrene molecules would have occupied majority of the micropore sites of the AC, rendering limited or no access for displacement by HPCD extraction. The authors suggested that HPCD extractability was reduced to a greater extent in the presence of AC and microbes had the capability to attach to black carbon surfaces to mineralise 14 C-phenanthrene.…”

Size‐Controlled Nanoassemblies Based on Cyclodextrin‐Modified Dextrans

“…Recent reviews report host-guest polymer assemblies originated from CD polymers and their biomedical applications. [15][16][17] Zhang and Ma [17] designed different nanocarriers for drug delivery based on a double hydrophilic block copolymer [a poly(ethylene oxide) block and a bCD-containing block]. bCD grafting PEI was proposed to build nanoparticles for drug and gene delivery.…”

Preparation of amphoteric N,O‐carboxymethyl hydroxypropyl chitosan by a two‐step reaction

“…Chitosan (CS) is a cationic polysaccharide obtained by the partial deacetylation of chitin, which originates from the shells of crustaceans and has been the second most abundant natural polysaccharide after cellulose . CS has many advantages, such as abundant resources, nontoxicity, biodegradability, biocompatibility, and antibacterial properties; thus, it has been widely used in the fields of agriculture, pharmaceuticals, cosmetics, food industries, environmental protection, and biotechnology .…”