Self-assembly and cellular distribution of a series of transformable peptides

Gong, Xue-Feng; Qi, Gao-Feng; Li, Yijing; Zhang, Kuo; Gao, Yong-Hong; Wang, Dong; Cao, Hui; Yang, Zhou; Wang, Lei

doi:10.1039/d1tb02814f

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…An amino acid chain was synthesized first, and then the bis-pyrene (BP) molecule was eventually conjugated to the N-terminal of the amino acid residual. 44 The BET peptide was further purified by high-performance liquid chromatography (HPLC) (Fig. S3b, ESI†).…”

Section: Resultsmentioning

confidence: 99%

A peptide selectively recognizes Gram-negative bacteria and forms a bacterial extracellular trap (BET) through interfacial self-assembly

Sha,

Lv,

Chen

et al. 2024

J. Mater. Chem. B

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Section: Resultsmentioning

confidence: 99%

A peptide selectively recognizes Gram-negative bacteria and forms a bacterial extracellular trap (BET) through interfacial self-assembly

Sha,

Lv,

Chen

et al. 2024

J. Mater. Chem. B

Self Cite

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“…165 Bispyrene (BP) molecules, which are non-fluorescent in their monomeric state, can exhibit fluorescent effects when they selfaggregate into NPs in aqueous solutions due to their hydrophobicity and p-p interactions. 166 This fluorescence effect is commonly utilized to monitor the self-assembly/disassembly processes both in vitro and in vivo. Qiao et al 167 employed thermoresponsive polymers to modulate the self-assembly of BP.…”

Section: Exogenous Stimulimentioning

confidence: 99%

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Yan¹,

Liu²,

Zhao³

et al. 2023

Mater. Horiz.

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Gold Nanoparticles‐Modified 2D Self‐Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency

Xu,

He,

et al. 2024

Macromol. Rapid Commun.

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Amphiphilic peptides have garnered significant attention due to their highly designable and self‐assembling behaviors. Self‐assembled peptides hold excellent potential in various fields such as biosensing, environmental monitoring, and drug delivery, owing to their remarkable biological, physical, and chemical properties. While nanomaterials formed by peptide self‐assembly have found widespread use in biomedical applications, the development of 2D peptide nanosheets based on the self‐assembly of amphiphilic peptides remains challenging in terms of rational design and morphology modulation. In this study, rationally designed amphiphilic peptide molecules are self‐assembled into peptide nanosheets (PNS) under specific conditions to encapsulate gold nanoparticles (AuNPs), resulting in the formation of AuNPs/PNS hybrid materials with high photothermal conversion efficiency. The findings demonstrate that 2D PNS enhances the overall photothermal therapy effect of the nanohybrid materials due to their larger hosting area for AuNPs and higher biocompatibility. The well‐designed amphiphilic peptides in this study offer insights into the structural design and functional modulation of self‐assembled molecules. In addition, the constructed biomimetic‐functional 2D inorganic/organic nanohybrid materials hold potential applications in biomedical engineering.

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Self-assembly and cellular distribution of a series of transformable peptides

Abstract: Transformable peptides (TPs) are biomedical materials with unique structures and diverse functionalities that have drawn great interest in material science and nanomedicine. Here, we design a series of TPs with...

Cited by 3 publications

References 33 publications

A peptide selectively recognizes Gram-negative bacteria and forms a bacterial extracellular trap (BET) through interfacial self-assembly

A peptide selectively recognizes Gram-negative bacteria and forms a bacterial extracellular trap (BET) through interfacial self-assembly

In situ stimulus-responsive self-assembled nanomaterials for drug delivery and disease treatment

Gold Nanoparticles‐Modified 2D Self‐Assembled Amphiphilic Peptide Nanosheets with High Biocompatibility and Photothermal Therapy Efficiency

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