Self‐assembly and chiral recognition of quartz crystal microbalance chiral sensor

Luo, Miao Li; Zhang, Wei Guang; Zhang, Sheng; Fan, Jun; Su, Wen Cui; Yin, Xian‐Hong

doi:10.1002/chir.20756

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…The larger binding constant K A means more stable complex formed between SA and single enantiomer. The chiral recognition factor ( α UV ) was determined using Equation ():

α_{italicUV} = 2 \frac{(||, lg K_{R} - lg K_{S})}{lg K_{R} + lg K_{S}}

…”

Section: Resultsmentioning

confidence: 99%

“…The immobilization processes of SAs on QCM crystals were measured by a home‐made flow injection analysis (FIA) system, which was similar to that used in the reported literature . Chiral discrimination was investigated by using a home‐made QCM gas system described previously …”

Section: Methodsmentioning

confidence: 99%

“…The SA‐fabricated QCM biosensors were mounted in the gas phase pulse‐measuring system, a vaporization pad that allowed microscale enantiomeric samples to be evaporated. Predried pure nitrogen was used as carrier gas.…”

Section: Methodsmentioning

confidence: 99%

“…28 Chiral discrimination was investigated by using a home-made QCM gas system described previously. 27,29 The Fabrication Procedure of Serum Albumin Self-Assembled Quartz Crystal Microbalance Biosensor…”

Section: Quartz Crystal Microbalance Systemmentioning

confidence: 99%

“…The QCM chiral discrimination factor a QCM of five pairs of enantiomers for both the GSA and RbSA sensors were calculated according to Equation (2): 27,29…”

Section: Real-time Chiral Recognition Of Enantiomers By Goat Serum Almentioning

confidence: 99%

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A New Biosensor for Chiral Recognition Using Goat and Rabbit Serum Albumin Self‐Assembled Quartz Crystal Microbalance

Chen

Zhang

et al. 2012

Chirality

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Quartz crystal microbalance (QCM) biosensor was used for the chiral recognition of five pairs of enantiomers by using goat serum albumin (GSA) and rabbit serum albumin (RbSA) as chiral selectors. Serum albumin (SA) was immobilized on the QCM through the self-assembled monolayer technique, and the surface concentration of GSA and RbSA were 8.8 × 10(-12) mol cm(-2) and 1.2 × 10(-11) mol cm(-2) , respectively. The QCM biosensors showed excellent sensitivity and selectivity. Meanwhile, the chiral recognition of SA sensors was quite species dependent. There were differences between GSA and RbSA sensors in the ability and the preference of chiral recognition. To R,S-1,2,3,4-tetrahydro-1-naphthylamine (R,S-1-TNA), R,S-1-(4-methoxyphenyl)ethylamine (R,S-4-MPEA), and R,S-1-(3-methoxyphenyl)ethylamine (R,S-3-MPEA), the preference of the stereoselective SA-drug binding of the two kinds of SA sensors were consistent. However, to R,S-2-octanol (R, S-2-OT) and R,S-methyl lactate (R,S-MEL), the two kinds of SA sensors had opposite chiral recognition preference. Moreover, the interactions of SA and the five pairs of enantiomers have been further investigated through ultraviolet (UV) and fluorescent (FL) spectra. The UV/FL results were in accordance with the consequence of QCM.

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“…The larger binding constant K A means more stable complex formed between SA and single enantiomer. The chiral recognition factor ( α UV ) was determined using Equation ():

α_{italicUV} = 2 \frac{(||, lg K_{R} - lg K_{S})}{lg K_{R} + lg K_{S}}

…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Quartz Crystal Microbalance Systemmentioning

confidence: 99%

“…The QCM chiral discrimination factor a QCM of five pairs of enantiomers for both the GSA and RbSA sensors were calculated according to Equation (2): 27,29…”

Section: Real-time Chiral Recognition Of Enantiomers By Goat Serum Almentioning

confidence: 99%

See 3 more Smart Citations

A New Biosensor for Chiral Recognition Using Goat and Rabbit Serum Albumin Self‐Assembled Quartz Crystal Microbalance

Chen

Zhang

et al. 2012

Chirality

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Advanced Applications of Nanoscale Measuring System for Biosensors

Kim

Chang²

2018

Emerging Areas in Bioengineering

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Eine enantioselektive elektronische Nase: Ein Array nanoporöser homochiraler MOF‐Filme zur stereospezifischen Erkennung chiraler Geruchsmoleküle

et al. 2020

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Chiralität ist von wesentlicher Bedeutung in der Natur und oft entscheidend für biologischen Informationstransfer, z. B. mittels Geruchsmolekülen. Während die menschliche Nase die Enantiomere vieler chiraler Gerüche unterscheiden kann, bleibt die technische Umsetzung durch einen künstlichen Sensor oder eine elektronische Nase, e‐nose, eine große Herausforderung. Hier präsentieren wir ein Array von sechs Sensoren, die mit nanoporösen Metall‐organischen Gerüsten (MOFs) verschiedener homochiraler und achiraler Strukturen beschichtet sind. Dieses Array funktioniert wie eine enantioselektive elektronische Nase. Während die achiralen MOF‐Sensoren identische Reaktionen für beide Isomere eines chiralen Geruchsmoleküls zeigen, unterscheiden sich die Sensorsignale der homochiralen MOF‐Filme bei verschiedenen Enantiomeren. Mittels maschineller Lern‐Algorithmen ermöglichen die kombinierten Arraydaten die stereoselektive Identifizierung, hier für fünf Paare von chiralen Geruchsmolekülen getestet. Wir sind überzeugt, dass die “chiral‐MOF‐e‐nose”, welche chirale Gerüche enantioselektiv erkennen und unterscheiden kann, zur fortgeschrittenen technischen Geruchswahrnehmung beiträgt.

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Self‐assembly and chiral recognition of quartz crystal microbalance chiral sensor

Cited by 14 publications

References 13 publications

A New Biosensor for Chiral Recognition Using Goat and Rabbit Serum Albumin Self‐Assembled Quartz Crystal Microbalance

A New Biosensor for Chiral Recognition Using Goat and Rabbit Serum Albumin Self‐Assembled Quartz Crystal Microbalance

Advanced Applications of Nanoscale Measuring System for Biosensors

Eine enantioselektive elektronische Nase: Ein Array nanoporöser homochiraler MOF‐Filme zur stereospezifischen Erkennung chiraler Geruchsmoleküle

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