Self-assembly and Patterning of Nanocrystals

Masuda, Yoshitake

doi:10.5772/23413

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…have been explored by scientist [15]. In comparison to the matrix and encapsulated type particles in which drug is distributed evenly on the surface and present in the center/core, respectively, which make total drug less than 100% available always but nanocrystal consist of 100% drug which makes them highly efficient in transporting the drug into the cells, reaching a sufficiently high therapeutic concentration for the pharmacological effect [16]. The Nano crystallization techniques are mainly divided into bottom-up, top-down and (mixed) combinatorial approaches [17].…”

Section: Nanocrystalization: An Emerging Technology To Enhance the Bimentioning

confidence: 99%

Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

Joshi

Chandra

Jain

et al. 2019

PNT

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Most of the active pharmaceutical ingredient used in the management of disease have poor water solubility and offer grueling problems in drug formulation development since low solubility is generally associated with poor dissolution characteristics which leads to poor oral bioavailability. The great challenge for the development of a pharmaceutical product is to create its new formulation and drug delivery system to limit solubility problems of existing drug candidate. Limited drug-loading capacity requires a large amount of carrier material to get appropriate encapsulation of the drug, which is another major challenge in the development of pharmaceutical product which could be resolved by developing nanocrystals (NCs). A significant research in the past few years has been done to develop NCs which helps in the delivery of poorly water soluble drugs via different routes. The technology could continue to thrive as a useful tool in pharmaceutical sciences for the improvement of drug solubility, absorption and bioavailability. Many crystalline compounds have pulled in incredible consideration much of the time, due to their ability to show good physical and chemical properties when contrasted with their amorphous counterparts. Nanocrystals have been proven to show atypical properties compared to the bulk. This review article explores the principles of the important nanocrystallization techniques including NCs characterization and its application.

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Section: Nanocrystalization: An Emerging Technology To Enhance the Bimentioning

confidence: 99%

Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

Joshi

Chandra

Jain

et al. 2019

PNT

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show abstract

“…[18][19][20][21][22]. Again, nucleation and growth of nanoparticles directly in the polymer films should have a number of benefits as compared to incorporation of the pre-made nanoparticles into polymer films formed on the solid surface.…”

Section: Introductionmentioning

confidence: 99%

Thin polymer films grafted to the solid surface with in situ synthesized CdS nanocrystals

et al. 2015

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Combining two different novel techniques, namely Bgrafting from^polymerization and in situ sol-gel synthesis, nanocomposites based on CdS nanocrystals embedded into thin polymer films with diverse structure (either poly(acrylic acid) (PAA) homopolymer or mosaic one composed of polystyrene (PS) and PAA chains) grafted to the solid surface have been obtained. The structure of grafted polymer films as well as the composition of obtained on their basis nanocomposite films were studied and characterized by UV-visible spectroscopy, IR-spectroscopy, scanning electron microscopy, and atomic-force microscopy. Two fractions of CdS nanocrystals with the sizes of~4.5-4.7 and~5.7-6.0 nm formed in polymer films of both types have been found. It has been revealed that the content ratio of these two fractions mostly depends on the structure of polymer films.

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Self-assembly and Patterning of Nanocrystals

Cited by 2 publications

References 14 publications

Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

Thin polymer films grafted to the solid surface with in situ synthesized CdS nanocrystals

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