Self-Assembly Behavior of Thermoresponsive Oligo(ethylene glycol) Methacrylates Random Copolymer

Peng, Baoliang; Grishkewich, Nathan; Yao, Zhaoling; Han, Xia; Liu, Honglai; Tam, Kam Chiu

doi:10.1021/mz300135x

Cited by 55 publications

(55 citation statements)

References 30 publications

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“…16 In this work, the authors take advantage of the relationship between oligoethylene glycol chain length and temperature sensitivity. Here, 2-(2-methoxyethoxy) ethyl methacrylate (MEO2MA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) copolymers were synthesized by ATRP.…”

Section: Physical-physical Dual Stimuli-responsive Macromoleculesmentioning

confidence: 99%

Multi-stimuli responsive macromolecules and their assemblies

et al. 2013

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In this review, we outline examples that illustrate the design criteria for achieving macromolecular assemblies that incorporate a combination of two or more chemical, physical or biological stimuli-responsive components. Progress in both fundamental investigation into the phase transformations of these polymers in response to multiple stimuli and their utilization in a variety of pratical applications have been highlighted. Using these examples, we aim to explain the origin of employed mechanisms of stimuli responsiveness which may serve as a guideline to inspire future design of multi-stimuli responsive materials.

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Section: Physical-physical Dual Stimuli-responsive Macromoleculesmentioning

confidence: 99%

Multi-stimuli responsive macromolecules and their assemblies

et al. 2013

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“…8,20,21 Unlike poly(ethylene glycol) (PEG), which can only be end-group functionalized, the free radical (co)polymerization method used to produce POEGMA enables the incorporation of a range of reactive comonomers or cross-linkers, facilitating production of pre-gel precursor polymers with a range of desired chemistries, cross-link densities, and molecular weights. We have previously reported extensively on modular POEGMA hydrogels cross-linked via hydrazone bonds, formed by reactive extrusion of aldehyde and hydrazide-functionalized precursor polymers.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

2016

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While injectable hydrogels have several advantages in the context of biomedical use, their generally weak mechanical properties often limit their applications. Herein we describe in situgelling nanocomposite hydrogels based on poly(oligoethylene glycol methacrylate) (POEGMA) and rigid rod-like cellulose nanocrystals (CNCs) that can overcome this challenge. By physically incorporating CNCs into hydrazone cross-linked POEGMA hydrogels, macroscopic properties including gelation rate, swelling kinetics, mechanical properties, and hydrogel stability can be readily tailored. Strong adsorption of aldehyde and hydrazide modified POEGMA precursor polymers onto the surface of CNCs promotes uniform dispersion of CNCs within the hydrogel, imparts physical cross-links throughout the network, and significantly improves mechanical strength overall, as demonstrated by quartz crystal microbalance gravimetry and rheometry.When POEGMA hydrogels containing mixtures of long and short ethylene oxide side chain precursor polymers were prepared, transmission electron microscopy reveals that phase segregation occurs with CNCs hypothesized to preferentially locate within the stronger adsorbing short side chain polymer domains. Incorporating as little as 5 wt % CNCs results in dramatic enhancements in mechanical properties (up to 35-fold increases in storage modulus) coupled with faster gelation rates, decreased swelling ratios, and increased stability versus hydrolysis. Furthermore, cell viability can be maintained within 3D culture using these hydrogels independent of the CNC content. These properties collectively make POEGMA-CNC

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“…[ 28,29 ] Subsequently, a variety of polymer brushes, micelles, vesicles, micro/nanogels, as well as a few of smart hydrogels based on POEGMA have been developed in the past few years. [30][31][32][33] For instance, Huck and co-workers reported that surface attached P(MEO 2 MA -co-OEGMA) brushes exhibited a fast and reversible thermo-induced collapse transition, resulting in different surface properties of the polymer coating below and above the LCST. [ 34 ] Roth et al showed that POEGMA based copolymers also exhibit a UCST behavior in alcohol/ water mixtures.…”

Section: Introductionmentioning

confidence: 99%

Thermo‐Induced Double Phase Transition Behavior of Physically Cross‐Linked Hydrogels Based on Oligo(ethylene glycol) methacrylates

Cheng

Théato

Zhu

2015

Macro Chemistry & Physics

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Double thermosensitive clay/P(MEO 2 MA -co-POEGMA) nanocomposite (NC) hydrogels are prepared by in situ free radical polymerization of 2-(2-methoxyethoxy) ethyl methacrylate (MEO 2 MA) and oligo(ethylene glycol) methacrylate (OEGMA) in the presence of physical crosslinker clay. The temperature-induced phase transition behavior of NC hydrogels is investigated by turbidity, temperature dependent nuclear magnetic resonance, and variable temperature Fourier transform infrared spectroscopy. 2D infrared analysis is employed to study the sequential order of changes of all groups in NC hydrogels during the heating and cooling process. The obtained novel clay/P(MEO 2 MA -co-POEGMA) NC hydrogels exhibit an unusual thermally induced multistep aggregation process and successively undergo three consecutive microstructural changes: "loose clay/polymer microaggregation ↔ homogeneous network structure ↔ dense clay/polymer macroaggregation." Dynamic light scattering and transmission electron microscopy measurements show similar results of the NC nanogel at the same temperature regions, confi rming the three consecutive microstructural changes. This new generation of thermosensitive hydrogel offers promising potential for applications as smart devices, biomedical materials, and drug carriers.

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Self-Assembly Behavior of Thermoresponsive Oligo(ethylene glycol) Methacrylates Random Copolymer

Cited by 55 publications

References 30 publications

Multi-stimuli responsive macromolecules and their assemblies

Multi-stimuli responsive macromolecules and their assemblies

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

Thermo‐Induced Double Phase Transition Behavior of Physically Cross‐Linked Hydrogels Based on Oligo(ethylene glycol) methacrylates

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