Self-Assembly in Micro- and Nanofluidic Devices: A Review of Recent Efforts

Khoo, Hwa Seng; Lin, Cheng; Huang, Shu‐Mei; Tseng, Fan‐Gang

doi:10.3390/mi2010017

Cited by 30 publications

(21 citation statements)

References 123 publications

(150 reference statements)

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“…Elaborately synthesized lipid vesicles are required in a variety of research areas such as biology and pharmacology due to the biocompatibility and structural stability of unilamellar lipid vesicles . To date, lipid vesicles of different sizes have been applied in the fields of liposome–hydrogel hybrid nanoparticles , targeted drug delivery , ultrasound imaging , artificial lipid bilayer study , and mammalian cell modeling .…”

Section: Introductionmentioning

confidence: 99%

On‐chip generation of monodisperse giant unilamellar lipid vesicles containing quantum dots

Park

Lee

et al. 2016

Electrophoresis

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Monodispersed lipid vesicles have been used as a drug delivery vehicle and a biochemical reactor. To generate monodispersed lipid vesicles in the nano- to micrometer size range, an extrusion step should be included in conventional hand-shaking method of lipid vesicle synthesis. In addition, lipid vesicles as a drug carrier still need to be improved to effectively encapsulate concentrated biomolecules such as cells, proteins, and target drugs. To overcome these limitations, this paper reports a new microfluidic platform for continuous synthesis of small-sized (∼10 μm) giant unilamellar vesicles (GUVs) containing quantum dots (QDs) as a nanosized model drug. To generate GUVs, we introduced an additional cross-flow to break vesicles into small size. 1,2 - dimyristoyl-sn-glycero - 3 - phosphocholine (DMPC) in an octanol-chloroform mixture was used in the construction of self-assembled membrane. Consequently, we have successfully demonstrated the fabrication of monodispersed GUVs with 7-12 μm diameter containing QDs. The proposed synthesis method of cell-sized GUVs would be highly desirable for applications such as multipurpose drug encapsulation and delivery.

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Section: Introductionmentioning

confidence: 99%

On‐chip generation of monodisperse giant unilamellar lipid vesicles containing quantum dots

Park

Lee

et al. 2016

Electrophoresis

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“…16 It has been successfully used for the assembly of nanoparticles [17][18][19] or carbon nanotubes, 21 as well as cells 20 or vesicles 22 within arrays of microwells. 23 These techniques often use micro-or nanostructured substrates that perturb the dewetting process.…”

Section: Introductionmentioning

confidence: 99%

Elongated unique DNA strand deposition on microstructured substrate by receding meniscus assembly and capillary force

et al. 2014

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Ordered deposition of elongated DNA molecules was achieved by the forced dewetting of a DNA solution droplet over a microstructured substrate. This technique allows trapping, uncoiling, and deposition of DNA fragments without the need of a physicochemical anchoring of the molecule and results in the combing of double stranded DNA from the edge of microwells on a polydimethylsiloxane (PDMS) substrate. The technique involves scanning a droplet of DNA solution caught between a movable blade and a PDMS substrate containing an array of microwells. The deposition and elongation appears when the receding meniscus dewets microwells, the latter acting here as a perturbation in the dewetting line forcing the water film to break locally. Thus, DNA molecules can be deposited in an ordered manner and elongated conformation based solely on a physical phenomenon, allowing uncoiled DNA molecules to be observed in all their length. However, the exact mechanism that governs the deposition of DNA strands is not well understood. This paper is an analysis of the physical phenomenon occurring in the deposition process and is based on observations made with the use of high frame/second rate video microscopy. V C 2014 AIP Publishing LLC.

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“…Tubular and cubic cellular structures have been assembled based on simple exterior stimulations and manipulations [33,34]. Furthermore, different 3D microstructures have been assembled inside microfluidic channels with particular features, which show great potential for use in assembling 3D cellular structures [35].…”

mentioning

confidence: 99%

On-Chip Construction of Multilayered Hydrogel Microtubes for Engineered Vascular-Like Microstructures

Yue

Liu

et al. 2019

Micromachines

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Multilayered and multicellular structures are indispensable for constructing functional artificial tissues. Engineered vascular-like microstructures with multiple layers are promising structures to be functionalized as artificial blood vessels. In this paper, we present an efficient method to construct multilayer microtubes embedding different microstructures based on direct fabrication and assembly inside a microfluidic device. This four-layer microfluidic device has two separate inlets for fabricating various microstructures. We have achieved alternating-layered microtubes by controlling the fabrication, flow, and assembly time of each microstructure, and as well, double-layered microtubes have been built by a two-step assembly method. Modifications of both the inner and outer layers was successfully demonstrated, and the flow conditions during the on-chip assembly were evaluated and optimized. Each microtube was successfully constructed within several minutes, showing the potential applications of the presented method for building engineered vascular-like microstructures with high efficiency.

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Self-Assembly in Micro- and Nanofluidic Devices: A Review of Recent Efforts

Cited by 30 publications

References 123 publications

On‐chip generation of monodisperse giant unilamellar lipid vesicles containing quantum dots

On‐chip generation of monodisperse giant unilamellar lipid vesicles containing quantum dots

Elongated unique DNA strand deposition on microstructured substrate by receding meniscus assembly and capillary force

On-Chip Construction of Multilayered Hydrogel Microtubes for Engineered Vascular-Like Microstructures

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