Self-assembly nanoplatform of platinum (Ⅳ) prodrug for enhanced ovarian cancer therapy

Ma, Xiaojie; Liu, Yangjia; Wu, H. C.; Tan, Jinxiu; Yi, Wei; Wang, Zhenjie; Yu, Zhiqiang; Wang, Xuefeng

doi:10.1016/j.mtbio.2023.100698

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Synthetic approach is presented in Figure 1A. [26][27][28] The structure of OART was confirmed by 1 H-NMR, 13 C-NMR, HRMS, and HPLC, as shown in Figures S1-S4. The (3-(4,5-dimethylthiazol-2-yl)−2,5diphenyltetrazolium bromide) (MTT) assay reveals that OART exhibits extraordinary growth inhibition effect on multiple cancer cell lines, as shown in Figure 1B, which distinguishes it from both Oxa and ART.…”

Section: Oart Inhibits Tumor Cell Proliferation In Vitromentioning

confidence: 88%

A platinum(IV)–artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy

Fan,

Deng,

Lin

et al. 2024

MedComm

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Ferroptosis is an iron‐dependent cell death form that initiates lipid peroxidation (LPO) in tumors. In recent years, there has been growing interest on ferroptosis, but how to propel it forward translational medicine remains in mist. Although experimental ferroptosis inducers such as RSL3 and erastin have demonstrated bioactivity in vitro, the poor antitumor outcome in animal model limits their development. In this study, we reveal a novel ferroptosis inducer, oxaliplatin–artesunate (OART), which exhibits substantial bioactivity in vitro and vivo, and we verify its feasibility in cancer immunotherapy. For mechanism, OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via inhibiting glutathione‐mediated ferroptosis defense system, enhancing iron‐dependent Fenton reaction, and initiating mitochondrial LPO. The destroyed mitochondrial membrane potential, disturbed mitochondrial fusion and fission, as well as downregulation of dihydroorotate dehydrogenase mutually contribute to mitochondrial LPO. Consequently, OART enhances tumor immunogenicity by releasing damage associated molecular patterns and promoting antigen presenting cells maturation, thereby transforming tumor environment from immunosuppressive to immunosensitive. By establishing in vivo model of tumorigenesis and lung metastasis, we verified that OART improves the systematic immune response. In summary, OART has enormous clinical potential for ferroptosis‐based cancer therapy in translational medicine.

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Section: Oart Inhibits Tumor Cell Proliferation In Vitromentioning

confidence: 88%

A platinum(IV)–artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy

Fan,

Deng,

Lin

et al. 2024

MedComm

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“…For ferulic acid, metal coordination complexes with Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ , Mn 2+ , Mg 2+ , Fe 2+ , Fe 3+ and Na + are found [161][162][163][164][165][166][167][168][169][170]. For linoleic acid, metal complexes with Fe 2+ , Fe 3+ , Cu 2+ and Pt 2+ are described [171][172][173]. In general, metal complexes again show better antioxidant/antiinflammatory behavior than the free ligands.…”

Section: Discussing Unexpected Dose-response Curves In Natural Bioact...mentioning

confidence: 91%

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

Barreiro-Sisto,

Fernández-Fariña,

González-Noya

et al. 2024

IJMS

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This review aims to analyze the emerging number of studies on biological media that describe the unexpected effects of different natural bioactive antioxidants. Hormetic effects, with a biphasic response depending on the dose, or activities that are apparently non-dose-dependent, have been described for compounds such as resveratrol, curcumin, ferulic acid or linoleic acid, among others. The analysis of the reported studies confirms the incidence of these types of effects, which should be taken into account by researchers, discarding initial interpretations of imprecise methodologies or measurements. The incidence of these types of effects should enhance research into the different mechanisms of action, particularly those studied in the field of basic research, that will help us understand the causes of these unusual behaviors, depending on the dose, such as the inactivation of the signaling pathways of the immune defense system. Antioxidative and anti-inflammatory activities in biological media should be addressed in ways that go beyond a mere statistical approach. In this work, some of the research pathways that may explain the understanding of these activities are revised, paying special attention to the ability of the selected bioactive compounds (curcumin, resveratrol, ferulic acid and linoleic acid) to form metal complexes and the activity of these complexes in biological media.

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“…Besides, these pure nanomedicines typically have controllable components and extremely high drug loading contents. 20,21 More importantly, self-assembly of different chemotherapy drugs with photosensitizers to form nanomedicines can achieve efficient drug delivery while producing synergistic antitumor effects of chemotherapy/PTT. 22 Another attractive drug delivery platform is a hydrogel system.…”

Section: Introductionmentioning

confidence: 99%

pH/Temperature Dual-Sensitive Hydrogel Based on Carboxymethyl Chitosan and a Pluronic for Combined Chemo-Photothermal Therapy

Song,

Zhang,

Yang

et al. 2024

ACS Appl. Polym. Mater.

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The purpose of this paper is to design an injectable hydrogel containing nanodrugs for combined chemotherapy and photothermal therapy of tumors. Pluronic F127 was oxidized to aldehyde-terminated (AF127) as a precursor of the hydrogel. AF127 reacts with carboxymethyl chitosan to form a dynamic imine bond, thereby obtaining a hydrogel. Sorafenib and ICG were coassembled into a pure nanodrug (S–I NP) capable of combined chemotherapy and photothermal therapy (PTT). By incorporation of S–I NPs into the hydrogel, an injectable pH/temperature dual-responsive nanoparticle-hydrogel composite (S–I NPs@Gel) was obtained. S–I NPs@Gel can form a drug reservoir at the tumor site and gradually release S–I NPs in response to the tumor microenvironment. Sorafenib, a multitargeted antitumor drug, inhibits cell proliferation and induces apoptosis in liver cancer cells. ICG serves as an effective photosensitizer, absorbing near-infrared light to induce strong photothermal effects while generating reactive oxygen species (ROS) that induce cell apoptosis. MTT assay results demonstrate that S–I NPs@Gel exhibits the highest cell toxicity under laser irradiation, reaching 93.3%. Antitumor treatment results reveal that the tumor volume treated by S–I NPs@Gel under irradiation (808 nm, 2 W/cm2, 5 min) was only 382.9 ± 80.5 mm3, achieving a tumor growth inhibition rate of 93.5%. Thus, a locally administered system based on pH and temperature-sensitive hydrogels can effectively achieve synergistic antitumor effects.

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Self-assembly nanoplatform of platinum (Ⅳ) prodrug for enhanced ovarian cancer therapy

Cited by 4 publications

References 39 publications

A platinum(IV)–artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy

A platinum(IV)–artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy

Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation

pH/Temperature Dual-Sensitive Hydrogel Based on Carboxymethyl Chitosan and a Pluronic for Combined Chemo-Photothermal Therapy

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