Self-assembly of amphiphilic alternating copolymers with stimuli-responsive rigid pendant groups

Lv, Yisheng; Wang, Liquan; Liu, Fan; Feng, Weisheng; Wei, Jie; Lin, Shaoliang

doi:10.1039/d0py00765j

Cited by 8 publications

(6 citation statements)

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“…Chakraborty and coworkers designed a multi-stimuli temperature- and redox-responsive polymersome based on co-assembly of two π-amphiphiles containing an acceptor (A) (naphthalene diimide) and a donor (D) (pyrene) chromophore [ 104 ]. Different authors, such as Li [ 105 ] and Lv [ 106 ], among others [ 102 ], also obtained self-assembled polymersomes from alternating amphiphilic copolymers. Goswami et al developed vesicles assembled in water from alternating copolymers, prepared through RAFT polymerization of methoxy poly(ethylene glycol) (mPEG) functionalized styrene (VBP) and fatty acid attached maleimide (MF) monomers P(MF-alt-VBP) [ 101 ].…”

Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Polymersomes As a Platform For Anticancer Therapeutic Deliverymentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…We conducted dissipative particle dynamics (DPD) simulations on the hierarchical assembly of patchy nanoparticles. The DPD is a coarse-grained mesoscopic simulation approach for complex fluids. − The details of the DPD method can be found in Section 1 of the Supporting Information. The patchy nanoparticles are created by the self-assembly of rod–coil diblock copolymers and the crosslinking of coil blocks.…”

Section: Methods and Modelsmentioning

confidence: 99%

Crosslinking Modulated Hierarchical Self-Assembly of Rod–Coil Diblock Copolymer Patchy Nanoparticles

Feng

Wang

et al. 2021

Macromolecules

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Stepwise self-assembly of block copolymers offers a convenient route to structuring complex materials over multiple length scales. Still, the controllability and adjustability of such approaches need to be further improved. We proposed a crosslinking strategy and presented a computational study on the stepwise self-assembly of rod–coil diblock copolymers modulated by crosslinking. The computation results showed that the crosslinking number and rod block length determine the structure of transient patchy particles, which affect the morphology of hierarchical aggregates formed eventually. We discovered that the packing parameter of temporary patchy particles can effectively predict the geometry of hierarchical aggregates. In particular, we found that the stepwise self-assembly modulated by crosslinking can help build supracolloidal networks with hierarchy.

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“…To this end, in semi‐batch polymerizations, monomers are fed into the reaction mixture at programmed speed through syringe pumps. Sequence specific copolymers, such as multiblocks and strictly alternating AB copolymers, are also believed to have a high potential in the field of MSR polymers 103 . The latter are more conveniently obtained through ring‐opening and step‐growth polymerizations 104–108 .…”

Section: Background: Matching Building Block Studs For Specific Compositions Architectures and Functionsmentioning

confidence: 99%

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

D’Acunzo

Masci

2021

Journal of Polymer Science

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In this review article, we survey the 2016–June 2021 scientific literature on the synthesis of multi‐stimuli responsive (MSR) polymers, the main focus being on reversible deactivation radical polymerization techniques (RDRPs, also known as controlled radical polymerizations). In fact, along more than 40 years of extensive research, RDRPs have boosted the synthesis of stimuli‐responsive polymers. RDRPs are now robust, versatile, relatively user‐friendly and even interconvertible, thus allowing control over composition, sequence, and topology of polymers. Such control can afford materials with well‐defined responses to physical, chemical, and biological external stimuli. Furthermore, “click” reactions are used to combine macromolecular precursors or to introduce specific functional groups in the target structure. As a result, MSR polymers are obtained from diverse combinations of commercial or specially synthesized building blocks arranged at will into desired sequences and architectures. Thanks to this versatility, self‐assembling polymeric structures are designed either to respond to triggers and perform specific applicative tasks, or to investigate the influence of structural variables on the responsivity of polymers. The “green” trend emerging in the field of responsive polymers and RDRPs is also briefly discussed.

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Self-assembly of amphiphilic alternating copolymers with stimuli-responsive rigid pendant groups

Abstract:
Amphiphilic alternating copolymers (AACs) possess unique self-assembly behaviours owing to their unique regular architecture.

Cited by 8 publications

References 50 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Crosslinking Modulated Hierarchical Self-Assembly of Rod–Coil Diblock Copolymer Patchy Nanoparticles

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

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Self-assembly of amphiphilic alternating copolymers with stimuli-responsive rigid pendant groups

Abstract: Amphiphilic alternating copolymers (AACs) possess unique self-assembly behaviours owing to their unique regular architecture.

Cited by 8 publications

References 50 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Crosslinking Modulated Hierarchical Self-Assembly of Rod–Coil Diblock Copolymer Patchy Nanoparticles

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

Contact Info

Product

Resources

About

Abstract:
Amphiphilic alternating copolymers (AACs) possess unique self-assembly behaviours owing to their unique regular architecture.