Self‐Assembly of Amphiphilic Drug–Dye Conjugates into Nanoparticles for Imaging and Chemotherapy

Sun, Tingting; Lin, Wenhai; Zhang, Wei; Xie, Zhigang

doi:10.1002/asia.201601206

Cited by 16 publications

(8 citation statements)

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“…A group of conjugates based on BODIPY and paclitaxel was presented in the works [16][17][18]. Paclitaxel (Taxol) is the most commonly used cytostatic anti-cancer drug of natural origin.…”

Section: Bodipy-conjugates With Paclitaxelmentioning

confidence: 99%

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BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment

et al. 2022

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Fluorescent dyes absorbing and emitting in the visible and near-IR regions are promising for the development of fluorescent probes for labeling and bio-visualization of body cells. The ability to absorb and emit in the long-wavelength region increases the efficiency of recording the spectral signals of the probes due to the higher permeability of the skin layers. Compared to other fluorescent dyes, BODIPYs are attractive due to their excellent photophysical properties–narrow absorption and emission, intense fluorescence, simple signal modulation for the practical applications. As part of conjugates with biomolecules, BODIPY could act as a biomarker, but as therapeutic agent, which allows solving several problems at once-labeling or bioimaging and treatment based on the suppression of pathogenic microflora and cancer cells, which provides a huge potential for practical application of BODIPY conjugates in medicine. The review is devoted to the discussion of the recent, promising directions of BODIPY application in the field of conjugation with biomolecules. The first direction is associated with the development of BODIPY conjugates with drugs, including compounds of platinum, paclitaxel, chlorambucil, isoxazole, capsaicin, etc. The second direction is devoted to the labeling of vitamins, hormones, lipids, and other biomolecules to control the processes of their transport, localization in target cells, and metabolism. Within the framework of the third direction, the problem of obtaining functional optically active materials by conjugating BODIPY with other colored and fluorescent particles, in particular, phthalocyanines, is being solved.

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“…A group of conjugates based on BODIPY and paclitaxel was presented in the works [16][17][18]. Paclitaxel (Taxol) is the most commonly used cytostatic anti-cancer drug of natural origin.…”

Section: Bodipy-conjugates With Paclitaxelmentioning

confidence: 99%

“…A three-component amphiphilic conjugate 21 (Scheme 12) containing BODIPY-fluorophore, paclitaxel, and a platinum compound was presented in [17]. The conjugate could selfassemble into spherical nanoparticles with high stability in aqueous solution.…”

Section: Bodipy-conjugates With Paclitaxelmentioning

confidence: 99%

BODIPY Conjugates as Functional Compounds for Medical Diagnostics and Treatment

et al. 2022

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“…Self-assembly of organic molecules to form nanoparticles is more conducive to increasing drug loading and obtaining better water solubility than using drug carriers. [41][42][43] Wang et al [44] combined 18β-glycyrrhetinic acid (GA, 3β-hydroxyl-11oxo-olean-12-ene-29-oic acid) with porphyrins to obtain amphiphilic porphyrins (TPP-GA) (Figure 2). TPP-GA can self-assemble into nanoparticles (TPP-GA NPs) with good water stability in aqueous solutions.…”

Section: Water-soluble Porphyrin-based Nanoparticlesmentioning

confidence: 99%

“…Self‐assembly of organic molecules to form nanoparticles is more conducive to increasing drug loading and obtaining better water solubility than using drug carriers [41–43] . Wang et al [44] .…”

Section: Porphyrin‐based Nanoparticles For Photodynamic Therapymentioning

confidence: 99%

Porphyrin‐Based Nanoparticles: A Promising Phototherapy Platform

Liu

Tian

et al. 2022

ChemPlusChem

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Phototherapy, including photodynamic therapy and photothermal therapy, is an emerging form of non‐invasive treatment. The combination of imaging technology and phototherapy is becoming an attractive development in the treatment of cancer, as it allows for highly effective therapeutic results through image‐guided phototherapy. Porphyrins have attracted significant interest in the treatment and diagnosis of cancer due to their excellent phototherapeutic effects in phototherapy and their remarkable imaging capabilities in fluorescence imaging, magnetic resonance imaging and photoacoustic imaging. However, porphyrins suffer from poor water solubility, low near‐infrared absorption and insufficient tumor accumulation. The development of nanotechnology provides an effective way to improve the bioavailability, phototherapeutic effect and imaging capability of porphyrins. This review highlights the research results of porphyrin‐based small molecule nanoparticles in phototherapy and image‐guided phototherapy in the last decade and discusses the challenges and directions for the development of porphyrin‐based small molecule nanoparticles in phototherapy.

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“…Multimodal bioimaging can accomplish accurate and rapid diagnosis for tumor nanotheranostic platforms. However, for some tumor treatment modalities such as photodynamic therapy (PDT), [6][7][8][9] sonodynamic therapy (SDT), 10,11 radiotherapy (RT), 12,13 and chemotherapy, [14][15][16] the treatment effect is primarily dependent on the oxygen concentration level. Due to the demand of high oxygen consumption of cancer cells and the lack of oxygen supply caused by abnormal tumor angiogenesis, cancer cells have a hypoxic microenvironment, which is a typical feature of most solid tumors.…”

Section: Introductionmentioning

confidence: 99%