Self-assembly of an MRI responsive agent under physiological conditions provides an extended time window for in vivo imaging

Abstract

An MRI-responsive agent that spontaneously self-assembles to a large supramolecular structure under physiological conditions was designed. The obtained assembly provides an extended time window for in vivo studies, as demonstrated...

Frontiers in19F-MR imaging: nanofluorides and19F-CEST as novel extensions to the19F-MRI toolbox

“…One solution could be the use of smart imaging agents that self-assemble into large architectures under physiological conditions. 33 Using this strategy, we demonstrated a prolonged 19 F-MRI signal of an injectable probe even 20 hours after its delivery without the need for continuous infusion. These principles can be generalized and implemented for other types of imaging agents, which require prolonged imaging times or cannot tolerate fast washout rates.…”

“…For example, activable probes to sense metal ions, 23 e.g. Zn 2+ , 24 Cu 2+ , 25 Mn 2+ 26 and enzymes, 2,27 or to detect alterations in the local environment, such as redox, 7,28,29 pH, [30][31][32] and temperature, 33,34 via changes in the 19 F-MR signal. Due to their signal specificity, stimuli-triggered probes have a wide range of applications and are particularly useful for quantifying parameters that influence their response.…”