Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review

Abstract

Carbohydrates are naturally occurring compounds that are biocompatible, biodegradable and offers good opportunities for chemical modifications. Also, it holds significant importance in numerous biological processes including immune response, growth regulation,...

A facile synthesis of amphiphilic N-glycosyl naphthalimides and fabrication of flexible semiconductors using molecular self-assembly

“…[53][54][55][56][57] In particular, selfassembly of carbohydrates, one of the important naturally occurring biocompatible and biodegradable molecules, renders an opportunity to achieve different functional architectures, which hold potential for application in electronic and bio sectors. [58][59][60][61][62][63][64][65] Seeberger and coworkers have summarized the advances in carbohydrate supramolecular chemistry, emphasizing carbohydrates as stabilizers of complex architectures. 66 Owing to the fascinating applications of assembled carbohydrate amphiphiles, we were curious to investigate the self-assembly of a series of amphiphilic N-Glycosyl Naphthalimides (NGN) judiciously designed by incorporating the salient structural features such as hydroxyl and amide linkage for hydrophilicity, alkyl chains to induce hydrophobicity and naphthalimide moiety for π-π staking.…”

Design, Synthesis, and Characterization of Novel Series of Pharmacologically-important Sperm-shaped Amphiphilic Heterocyclic Compounds derived from Natural Palmitic Acid

“…of all the four newly-synthesized compounds 2a-2d were perfectly compliant with the targeted chemical structures. In this model of amphiphilic structure (Figure 3), we can make use of this cocktail or hybrid pharmacophore in many different ways in pharmceutical and medicinal chemistry (Gao et al, 2021;Jubie et al, 2012;Mittal et al, 2021;Mushtaq et al, 2021;Rabie, 2021b). First, pharmacokinetically, if we want to design certain drugs that have all the three main states of gradual polarity (polar, semipolar, and nonpolar) to effectively be distributed and pass through the diverse biological liquids and membranes, hundreds of compounds can be easily synthesized based on this backbone.…”

Nanofiber Carriers of Therapeutic Load: Current Trends

“…Other than hydrophobic interactions which can govern NF self-assembly, directional interactions such as hydrogen bonds, metal coordination or π-π aromatic stacking or electrostatic interactions between oppositely charged polymers can be exploited [ 22 ]. Other types of amphiphiles can self-assemble into NFs, including carbohydrate-based polymers [ 23 , 24 ].…”