Self‐Assembly of Globular‐Protein‐Containing Block Copolymers

Olsen, Bradley D.

doi:10.1002/macp.201300235

Cited by 23 publications

(19 citation statements)

References 125 publications

(124 reference statements)

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“…Protein-polymer conjugates, for example, were created using a covalent binding maleimide-thiol coupling reaction to create bioconjugates. [33][34][35] These bioconjugates were also been used in self-assembly experiments, demonstrating the same phase diversity as related building blocks. [35] Other materials, such as polyoxometalate anionic metal-oxygen nanocages, have been successfully attached to polymer tethers via covalent bonds.…”

Section: Tethered Np Building Blocksmentioning

confidence: 93%

Rational design of nanomaterials from assembly and reconfigurability of polymer-tethered nanoparticles

2015

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Polymer-based nanomaterials have captured increasing interest over the past decades for their promising use in a wide variety of applications including photovoltaics, catalysis, optics, and energy storage. Bottom-up assembly engineering based on the self-and directed-assembly of polymer-based building blocks has been considered a powerful means to robustly fabricate and efficiently manipulate target nanostructures. Here, we give a brief review of the recent advances in assembly and reconfigurability of polymer-based nanostructures. We also highlight the role of computer simulation in discovering the fundamental principles of assembly science and providing critical design tools for assembly engineering of complex nanostructured materials.

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Section: Tethered Np Building Blocksmentioning

confidence: 93%

Rational design of nanomaterials from assembly and reconfigurability of polymer-tethered nanoparticles

2015

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“…Olsen et al systematically studied the phase behaviors of globular protein–polymer giant surfactant, mCherry‐ b ‐PNIPAM (mChP), in concentrated aqueous solution as a function of the giant surfactant concentration, the solution temperature, and the PNIPAM coil fraction. Both order–order transition and order–disorder transition were observed . Figure shows the phase diagrams for mChP with different coil fractions.…”

Section: Design and Synthesis Of Giant Surfactantsmentioning

confidence: 97%

“…Figure shows recent examples of giant surfactants based on various functionalized MNPs including carboxylic‐functionalized POSS, carboxylic‐functionalized C 60 , POM, and proteins . Molecular topology could also be precisely controlled for these giant surfactants.…”

Section: Design and Synthesis Of Giant Surfactantsmentioning

confidence: 99%

Giant surfactants based on molecular nanoparticles: Precise synthesis and solution self‐assembly

Dong

et al. 2014

J Polym Sci B Polym Phys

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Giant surfactants are polymer-tethered molecular nanoparticles (MNPs) and can be considered as a subclass of giant molecules. The MNPs serve as functionalized heads with persistent shape and volume, which may vary in size, symmetry, and surface chemistry. The covalent conjugation of MNPs and polymer tails affords giant surfactants with diverse composition and architecture. Synthetic strategies such as "graftingfrom" and "grafting-onto" have been successfully applied to the precise synthesis of giant surfactants, which is further facilitated by the emergence of "click" chemistry reactions. In many aspects, giant surfactants capture the essential features of small-molecule surfactants, yet they have much larger sizes. They bridge the gap between small-molecule surfactants and traditional amphiphilic macromolecules. Their self-assembly behaviors in solution are summarized in this Review. Micelle formation is affected not only by their primary chemical structures, but also by the experimental conditions. This new class of materials is expected to deliver general implications on the design of novel functional materials based on MNP building blocks in the bottom-up fabrication of well-defined nanostructures.

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“…In addition to careful selection of an immobilization method to preserve protein structures, successful application in films requires control of surface interactions to prevent denaturation at interfaces . A high protein loading is desirable in order to obtain high functionality per film area, and controlling protein orientation and transport through the material is critical for proper function, necessitating nanostructural control in protein‐immobilized materials …”

Section: Introductionmentioning

confidence: 99%

“…

per film area, [11] and controlling protein orientation and transport through the material is critical for proper function, necessitating nanostructural control in proteinimmobilized materials. [12] Many approaches have been developed to prepare nanostructured protein thin films, including lithographic patterning of 2D layers [13] and encapsulation in thicker films. Unstructured films of protein can be prepared by laser-assisted [14] or electrospray [15] deposition, and the resultant films have a very high protein density.

…”

mentioning

confidence: 99%

Kinetic Effects on Self‐Assembly and Function of Protein–Polymer Bioconjugates in Thin Films Prepared by Flow Coating

Chang

Huang

Olsen

2016

Macromol. Rapid Commun.

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The self-assembly of nanostructured globular protein arrays in thin films is demonstrated using protein-polymer block copolymers based on a model protein mCherry and the polymer poly(oligoethylene glycol acrylate) (POEGA). Conjugates are flow coated into thin films on a poly(ethylene oxide) grafted Si surface, forming self-assembled cylindrical nanostructures with POEGA domains selectively segregating to the air-film interface. Long-range order and preferential arrangement of parallel cylinders templated by selective surfaces are demonstrated by controlling relative humidity. Long-range order increases with coating speed when the film thicknesses are kept constant, due to reduced nucleation per unit area of drying film. Fluorescence emission spectra of mCherry in films prepared at <25% relative humidity shows a small shift suggesting that proteins are more perturbed at low humidity than high humidity or the solution state.

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Self‐Assembly of Globular‐Protein‐Containing Block Copolymers

Cited by 23 publications

References 125 publications

Rational design of nanomaterials from assembly and reconfigurability of polymer-tethered nanoparticles

Rational design of nanomaterials from assembly and reconfigurability of polymer-tethered nanoparticles

Giant surfactants based on molecular nanoparticles: Precise synthesis and solution self‐assembly

Kinetic Effects on Self‐Assembly and Function of Protein–Polymer Bioconjugates in Thin Films Prepared by Flow Coating

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