Self‐Assembly of Nucleic Acids

Carneiro, Karina M. M.; Lo, Pik Kwan; Sleiman, Hanadi F.

doi:10.1002/9780470661345.smc086

Cited by 2 publications

(3 citation statements)

References 89 publications

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“…DNA's ability to base pair with a complementary strand and its precise sequence programmability impart it with an unmatched level of molecular control. As well, biological and chemical strategies can be used to readily functionalize and modify nucleic acids 3…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we divide the combined top‐down and bottom‐up organization of nucleic acid materials on surfaces into three main sections: (1) directed patterning of naked DNA on surfaces,9 (2) long‐range self‐assembly of DNA with lipids and polymers through microphase separation,10 and (3) DNA nanotechnology, or self‐assembly of highly ordered DNA materials based on sequence design and DNA functionalization 8. This review will focus on long‐range materials, rather than smaller discrete structures from DNA, which are reviewed elsewhere 2,3,8…”

Section: Introductionmentioning

confidence: 99%

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Long‐range assembly of DNA into nanofibers and highly ordered networks

Carneiro

Avakyan

Sleiman

2013

WIREs Nanomed Nanobiotechnol

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Long-range assembly of DNA currently comprises both top-down and bottom-up methods. The top-down techniques consist of physical alignment of DNA and lithographic patterning to organize DNA on surfaces. The bottom-up approaches include lipid-and polymer-DNA co-assembly, the self-assembly of DNA amphiphiles, and the remarkably specific and versatile methods of DNA nanotechnology. DNA-based materials possess unprecedented molecular control and may offer innovative solutions in the fields of nanotechnology, sensing, nanomedicine, as well as optical and electronic devices. To realize the potential of these materials, a number of hurdles must be addressed. Bridging the gap between top-down fabrication and bottom-up assembly is of critical importance to the successful development of functional DNA-based technology. A profound understanding of both regimes is necessary to achieve this goal.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long‐range assembly of DNA into nanofibers and highly ordered networks

Carneiro

Avakyan

Sleiman

2013

WIREs Nanomed Nanobiotechnol

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“…polynucleotides, proteins) [39][40][41] exhibit higher order structures in the form of intricate folding patterns. Such folding behaviors and the precision with which they are executed are constant sources of inspiration for supramolecular chemists and drive the development of more complex synthetic architectures.…”

Section: Public Abstractmentioning

confidence: 99%

Explorations in crystal engineering

Duncan¹

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Explorations in crystal engineering : supramolecular templates, Explorations in crystal engineering : supramolecular templates, helical assemblies, pharmaceutical reactivity, and applications to helical assemblies, pharmaceutical reactivity, and applications to radio-imaging radio-imaging ____________________________________________ Michael Schultzii To Krista and Jasmine, Sasha, Tayla, Kenzie, and my loving parents iii I do not know what I may appear to the world, but to myself I seem to have been only like a boy playing on the sea-shore, and diverting myself in now and then finding a smoother pebble or a prettier shell than ordinary, whilst the great ocean of truth lay all undiscovered before me. Isaac Newtoniv ACKNOWLEDGEMENTSThere are a number of people I owe my success to, and I would like to take this space to offer them the most sincere love and gratitude for all the things they've done for me. Above all I must thank my research advisor, Professor Leonard R. MacGillivray. He has been a constant source of guidance in navigating the trials of earning a graduate degree. His mentoring has helped me hone my skills as a scientist and, looking back over the past six years, I can hardly believe how much my approach to research and problem solving has changed thanks to his influence. My gratitude to him is never-ending and I will continue to build on the foundation he has helped me establish as I continue in my career. Of course, I must thank the members of the MacGillivray research group, past and present: Beth, and Celymar. The insight, collaboration, and companionship they provided over the years will be some of the fondest memories from my time at Iowa. Also, I would like to thank the undergrads that worked with me, Roxie, Shawna, Kyle, Carlson, and Jeremy, who assisted me in my dissertation work. I am indebted to Dr. Dale Swenson for the enumerable times I bugged him in his office for help with crystallography. Dale never turned me away when I needed help working on a structure or needed advice on how to present and justify less-than-perfect quality data. I owe my knowledge and skill in X-ray crystallography to him and his generous teaching mentality. vi ABSTRACT Crystal engineering is a rapidly developing area of research with goals aimed at designing molecular solids with desired physical and chemical properties. By utilizing reliable intermolecular interactions, the principles of supramolecular chemistry are exploited in the solid state in order to achieve favorable arrangements of molecules in a crystal lattice. We have applied crystal engineering strategies to further develop the strategy of template-directed reactivity in the solid state. An evaluation of catechol, a regioisomer of the commonly used resorcinol template, was performed. Co-crystallization of the template candidate with a bis-pyridyl olefin produced a discrete self-assembled architecture wherein hydrogen-bonded dimers of catechol pre-organize the olefins for a[2+2] photodimerization in the solid state. The dimerization was determined to pro...

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Self‐Assembly of Nucleic Acids

Cited by 2 publications

References 89 publications

Long‐range assembly of DNA into nanofibers and highly ordered networks

Long‐range assembly of DNA into nanofibers and highly ordered networks

Explorations in crystal engineering

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