Self-assembly of Peptide dendrimers and their bio-applications in theranostics

Xie, Fengjuan; Li, Rongxin; Shu, Weikang; Zhao, Liang; Wan, Jingjing

doi:10.1016/j.mtbio.2022.100239

Cited by 35 publications

(24 citation statements)

References 77 publications

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“…A dendrimer can be built on virtually any form of chemistry, and the nature of that chemistry greatly influences its solubility, degradability, and biological activity [ 159 ]. Polyamidoamines (PAMAM) [ 160 ], poly- l -lysine (PLL) [ 161 ], polyamides (polypeptides) [ 162 ], poly (propylene imine) [ 163 ], and carbohydrates [ 164 ] are some of the most frequently used forms of dendrimers in biological applications. However, PAMAM dendrimers are the most prevalent dendrimer scaffold, commercially available with a wide range of generations and surface properties.…”

Section: Types Of Nanocarriersmentioning

confidence: 99%

A Recent Review on Cancer Nanomedicine

Giri

Banerjee

Layek

2023

Cancers

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Cancer is one of the most prevalent diseases globally and is the second major cause of death in the United States. Despite the continuous efforts to understand tumor mechanisms and various approaches taken for treatment over decades, no significant improvements have been observed in cancer therapy. Lack of tumor specificity, dose-related toxicity, low bioavailability, and lack of stability of chemotherapeutics are major hindrances to cancer treatment. Nanomedicine has drawn the attention of many researchers due to its potential for tumor-specific delivery while minimizing unwanted side effects. The application of these nanoparticles is not limited to just therapeutic uses; some of them have shown to have extremely promising diagnostic potential. In this review, we describe and compare various types of nanoparticles and their role in advancing cancer treatment. We further highlight various nanoformulations currently approved for cancer therapy as well as under different phases of clinical trials. Finally, we discuss the prospect of nanomedicine in cancer management.

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Section: Types Of Nanocarriersmentioning

confidence: 99%

A Recent Review on Cancer Nanomedicine

Giri

Banerjee

Layek

2023

Cancers

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“…The polyplexes are the artificial polymer-based carriers in which polyplexes and micelles are included. [37,50] There are numerous cationic polymers, such as polyethylenimine (PEI) [51] and its modifications, [52] poly-L-lysine (PLL) [53] and its derivatives, [54] dendric polymers polyamidoamine (pAMAM), [55] poly(2-dimethylaminoethyl methacrylate (pDMAEMA). [45,56] With proper peptide modification onto the branch, these dendric polymer derivatives can be self-assemble, cell-targeting.…”

Section: Polyplexes For Car-gene Deliverymentioning

confidence: 99%

“…[45,56] With proper peptide modification onto the branch, these dendric polymer derivatives can be self-assemble, cell-targeting. [50] These materials have been widely used in gene therapy, [57] especially the self-assembly of peptide dendrimers. [50] Olden et al designed poly(2-hydroxyethyl methacrylate-g-pDMAEMA polymers for mediated higher transfection efficiency.…”

Section: Polyplexes For Car-gene Deliverymentioning

confidence: 99%

Advanced Materials and Delivery Systems for Enhancement of Chimeric Antigen Receptor Cells

Li,

Luo,

et al. 2023

Small Methods

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Chimeric antigen receptor (CAR) cell therapy is a great success and breakthrough in immunotherapy. However, there are still lots of barriers to its wide use in clinical, including long time consumption, high cost, and failure against solid tumors. For these challenges, researches are deplored to explore CAR cells to more appliable products in clinical. This minireview focuses on the advanced non‐viral materials for CAR‐T transfection ex vivo with better performance, delivery systems combined with other therapy for enhancement of CAR‐T therapy in solid tumors. In addition, the targeted delivery platform for CAR cells in vivo generation as a breakthrough technology as its low cost and convenience. In the end, the prospective direction and future of CAR cell therapy are discussed.

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“…The synthesis of dendrimers makes it possible to control each stage of generation, resulting in a strictly defined structure [ 8 ]. There are various types of dendrimers, including phosphorus (P-dendrimers) [ 9 ], polyamidoamines (PAMAM) [ 10 ], polyamines [ 11 ], polyamides [ 12 ], polypeptides [ 13 ], polyesters [ 14 ], carbosilicates (CBS) [ 15 ], poly(L-lysine) dendrimers (PLL) [ 16 ], polyesters (PGLSA-OH) [ 17 ], poly (2,2) acid dendrimers -bis (hydroxymethyl) propionic (bis-MPA) [ 18 ], and peptide dendrimers [ 19 ]. In addition, we also distinguish dendrimers based on sugar units and oligonucleotides.…”

Section: Introductionmentioning

confidence: 99%

Application of Dendrimers in Anticancer Diagnostics and Therapy

2022

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The application of dendrimeric constructs in medical diagnostics and therapeutics is increasing. Dendrimers have attracted attention due to their compact, spherical three-dimensional structures with surfaces that can be modified by the attachment of various drugs, hydrophilic or hydrophobic groups, or reporter molecules. In the literature, many modified dendrimer systems with various applications have been reported, including drug and gene delivery systems, biosensors, bioimaging contrast agents, tissue engineering, and therapeutic agents. Dendrimers are used for the delivery of macromolecules, miRNAs, siRNAs, and many other various biomedical applications, and they are ideal carriers for bioactive molecules. In addition, the conjugation of dendrimers with antibodies, proteins, and peptides allows for the design of vaccines with highly specific and predictable properties, and the role of dendrimers as carrier systems for vaccine antigens is increasing. In this work, we will focus on a review of the use of dendrimers in cancer diagnostics and therapy. Dendrimer-based nanosystems for drug delivery are commonly based on polyamidoamine dendrimers (PAMAM) that can be modified with drugs and contrast agents. Moreover, dendrimers can be successfully used as conjugates that deliver several substances simultaneously. The potential to develop dendrimers with multifunctional abilities has served as an impetus for the design of new molecular platforms for medical diagnostics and therapeutics.

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Self-assembly of Peptide dendrimers and their bio-applications in theranostics

Cited by 35 publications

References 77 publications

A Recent Review on Cancer Nanomedicine

A Recent Review on Cancer Nanomedicine

Advanced Materials and Delivery Systems for Enhancement of Chimeric Antigen Receptor Cells

Application of Dendrimers in Anticancer Diagnostics and Therapy

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