Self‐assembly Promoted Crystallization of Diblock Copolypeptoids in Solution^†

Abstract

Comprehensive SummaryGreat efforts have been lately devoted to fabricating well‐defined nanostructures using crystallization‐driven self‐assembly (CDSA) strategy. The influence of self‐assembly on crystallization is also of great interest. Here, a series of amphiphilic diblock copolypeptoids poly(N‐allylglycine)‐b‐poly(N‐octylglycine) modified with cysteamine hydrochloride ((PNAG‐g‐NH2)‐b‐PNOG) were synthesized by ring‐opening polymerization (ROP) and post‐polymerization functionalization. The diblock copolypeptoid is comprised of one hydrophobic crystalline PNOG block and one hydrophilic amorphous block, which can aggregate into nanostructured assemblies with soluble PNAG‐g‐NH2 as the corona layer and PNOG as the inner core in aqueous solution. With a systematic study by differential scanning calorimetry (DSC) and wide‐angle X‐ray scattering (WAXS), we demonstrated that the self‐assembly of the block copolymers strengthens the crystallization of the PNOG block.

Zwitterionic Polyelectrolyte Complex Vesicles Assembled from Homopoly(2-Oxazoline)s as Enzyme Catalytic Nanoreactors for Potent Anti-Tumor Efficiency

“…Poly(2-oxazoline)s are peptidomimetic polymers that possess similar chemical structure to polypeptides yet are devoid of hydrogen-bond donating sites and chirality. − This results in tunable molecular interactions, processability, and excellent water affinity, offering an excellent nanoreactor platform. ,, By employing ring-opening polymerization (ROP) of BuOxz, we synthesized oppositely charged PBuOxz 80 with a degree of polymerization (DP) of 80 and a dispersity ( D̵ ) of 1.31 according to the reported procedure (Figures S2–S4). The PBuOxz 80 precursor was subsequently quantitatively modified with cysteamine hydrochloride and 3-mercaptopropionic acid to obtain PBuOxz 80 - g -NH 2 and PBuOxz 80 - g -COOH, respectively. , The molecular structures and characteristics of these polymers were confirmed by 1 H NMR spectroscopy and GPC.…”

AMP-Mimetic Antimicrobial Polymer-Involved Synergic Therapy with Various Coagents for Improved Efficiency

“…Poly( N -substituted glycine)s (polypeptoids) as one type of the peptidomimetic polymers have similar chemical structure to the polypeptides, but the side chain is attached to nitrogen. ,− Due to excellent biocompatibility, good solubility, and excellent enzymatic stability, polypeptoids have been widely used in biomedical fields such as antibacterial, antifouling, gene transfection, drug delivery, and diagnosis. , Our groups have synthesized a series of polypeptoids containing sulfonium motifs through NCA ring-opening polymerization (ROP) and subsequent modification. These polymers exhibit excellent antibacterial activity against S. aureus , low hemolytic properties, and good biocompatibility in vitro. , As shown in Figure , we synthesized a series of copolypeptoids containing positively charged primary amine side groups and alkyl chain side groups by NCA ROP .…”