Self‐Assembly Strategy for the Preparation of Polymer‐Based Nanoparticles for Drug and Gene Delivery

Chen, Si; Cheng, Si‐Xue; Zhuo, Ren‐Xi

doi:10.1002/mabi.201000427

Cited by 82 publications

(75 citation statements)

References 110 publications

(106 reference statements)

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“…15,16 Expanding from these mechanisms, interest has recently focused on mediating self-assembly via crystallinity of assembly forming domain(s). Taking advantage of the technique known as "crystallizationdriven self-assembly," spherical micelles, cylindrical (fibrillar) micelles, comicelles, platelets, and scarf-like structures have been accessed by poly(ferrocenylsilane)-containing copolymers.…”

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confidence: 99%

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Brubaker¹,

Velluto²,

Demurtas³

et al. 2015

ACS Nano

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With proper control over copolymer design and solvation conditions, self-assembled materials display impressive morphological variety that encompasses nanoscale colloids as well as bulk three-dimensional architectures. Here we take advantage of both hydrophobicity and crystallinity to mediate supramolecular self-assembly of spherical micellar, linear fibrillar, or hydrogel structures by a family of highly asymmetric poly(ethylene glycol)-b-oligo(ethylene sulfide) (PEG-OES) copolymers. Assembly structural polymorphism was achieved with modification of PEG-OES topology (linear versus multiarm) and with precise, monomer-by-monomer control of OES length. Notably, all three morphologies were accessed utilizing OES oligomers with degrees of polymerization as short as three. These exceptionally small assembly forming blocks represent the first application of ethylene sulfide oligomers in supramolecular materials. While the assemblies demonstrated robust aqueous stability over time, oxidation by hydrogen peroxide progressively converted ethylene sulfide residues to increasingly hydrophilic and amorphous sulfoxides and sulfones, causing morphological changes and permanent disassembly. We utilized complementary microscopic and spectroscopic techniques to confirm this chemical stimulus-responsive behavior in self-assembled PEG-OES colloidal dispersions and physical gels. In addition to inherent stimulus-responsive behavior, fibrillar assemblies demonstrated biologically relevant molecular delivery, as confirmed by the dose-dependent activation of murine bone marrow-derived dendritic cells following fibril-mediated delivery of the immunological adjuvant monophosphoryl lipid A. In physical gels composed of either linear or multiarm PEG-OES precursors, rheologic analysis also identified mechanical stimulus-responsive shear thinning behavior. Thanks to the facile preparation, user-defined morphology, aqueous stability, carrier functionality, and stimuli-responsive behaviors of PEG-OES supramolecular assemblies, our findings support a future role for these materials as injectable or implantable biomaterials.

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confidence: 99%

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Brubaker¹,

Velluto²,

Demurtas³

et al. 2015

ACS Nano

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“…Nanoparticles are commonly obtained by nanoprecipitation, emulsion techniques (single or double), or electrospraying methods [3]. Several parameters such as the choice of the solvent, the use and the nature of the surfactant, the organic/aqueous solvent volume ratio, the mixing rate and time, do significantly affect the nanoparticles characteristics and in particular their size [15,[151][152][153]. For example, nanoparticles derived from folic acid (FOL)-PHB with Dh ranging from 44 to 1132 nm (DLS) were obtained by modifying the sonication time during the double emulsion-solvent evaporation process from 30 to 5 min, respectively, without modifying their shape as assessed by scanning electron microscopy (SEM) of the nanoparticles [141].…”

Section: Preparation Methods and Characteristics Of Nanoparticles Dermentioning

confidence: 99%

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Barouti

Jaffredo

Guillaume

2017

Progress in Polymer Science

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International audienceWithin the general context of nanomedicine, drug delivery systems based on polymers have sparkeda rapidly growing interest and raised many efforts to tackle various diseases, among which cancer.Polyester-based nanoparticulate drug delivery systems, including polymer-drug conjugates andamphiphilic block copolymers, represent a major class with promising outcomes, especially for thosederived from poly(3-hydroxybutyrate) (PHB). This review describes recent advances in drug delivery systemsdesigned from the self-assembly of synthetic (co)polymers derived from PHB. The various strategiesfor the synthesis of PHB-conjugates, PHB/poly(ethylene glycol) (PEG) and other PHB-based copolymersare first summarized. Nanoparticles, micelles, microparticles, and hydrogels elaborated from these(co)polymers following various preparation methods, along with their exploitation in the encapsulationand release of various therapeutic agents, are next detailed. Finally, we discuss the synthetic challenges,drug delivery outlooks, and perspectives of PHB-based drug delivery systems. Engineered nano-scaledmaterials based on PHB self-assembled systems are thus anticipated to emerge as a valuable platformfor original drug delivery systems

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“…The polymeric nanomicelles are formed in the aqueous media through the self assembly of these copolymers due to hydrophobic interactions between water-insoluble segments, and can be utilized as synthetic carriers for drug delivery systems [1][2][3][4]. Amphiphilic block copolymers have attracted a great deal of attention in terms of their ability to form various types of nanoparticles referred to as micelles, nanocapsules, nanospheres, core-corona nanoparticles and so on [5].…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanomicelles using PLGA–PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values

Ashjari

Khoee

Mahdavian

et al. 2012

J Mater Sci: Mater Med

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Self-assembled nanomicelles can be used as synthetic biomaterials and colloidal carriers for poorly water-soluble drug delivery systems. Some of these micellar systems have been introduced in clinical trials and showed hopeful results relating to their therapeutic index in patients. Biodegradable nanomicelle was prepared from self-assembling amphiphilic block copolymer composed of poly(DL-lactic-co-glycolic acid) (PLGA) as a core and polyethylene glycol (PEG) as a corona. The PLGA-PEG block copolymer was first synthesized and characterized by FTIR, (1)H NMR, GPC and inherent viscosity measurements. The nanomicelle formed by PLGA-PEG block copolymer in the aqueous solution was characterized by dynamic light scattering, zeta potential, scanning electron microscopy (SEM) and fluorescence excitation and emission spectra of pyrene probe. The critical micelle concentration of obtained nanomicelle was about 0.006 mg/mL, with the size of about 160 nm and the zeta potential of -29 mV. Insulin-loaded PLGA-PEG nanomicelles were prepared by modified dialysis method and the physicochemical parameters of the micelles such as drug content, entrapment efficiency and in vitro drug release were characterized. The results showed that insulin was entrapped into PLGA-PEG nanomicelles with drug loading of 3.9 wt% and entrapment efficiency of 55 wt%. The nanomicelles containing insulin exhibited a controlled release profile. These observations suggested that the PLGA-PEG block copolymers nanomicelles have been prepared by a new synthetic route are potent nanocarrier for poorly water-soluble drugs as insulin.

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Self‐Assembly Strategy for the Preparation of Polymer‐Based Nanoparticles for Drug and Gene Delivery

Cited by 82 publications

References 110 publications

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Crystalline Oligo(ethylene sulfide) Domains Define Highly Stable Supramolecular Block Copolymer Assemblies

Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers

Self-assembled nanomicelles using PLGA–PEG amphiphilic block copolymer for insulin delivery: a physicochemical investigation and determination of CMC values

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