Abstract. In recent years, there has been stable production of grain industry products in volumes that meet the needs of the Tyumen region and allow the sale of products outside the region. The article is devoted to the study of territorial differentiation of the production of grain and leguminous crops in the Tyumen region. The purpose of the study is to assess the efficiency of grain production in the context of municipalities in the south of the Tyumen region and determine the dependence on the level of fertilizer application. Methods. Statistical methods of data processing (analysis of time series, method of variation, method of correlation-regression analysis), as well as cluster analysis using the Ward method, were used for the study. The scientific novelty lies in the fact that municipalities have been clustered and ranked according to a set of parameters characterizing the development of the grain production industry in the Tyumen region. Results. An assessment was made of the scale of industry development for the period from 2018 to 2022, quantitative and qualitative indicators were considered: the size of sown areas, gross yields, yields of grain and leguminous crops differentiated by municipal areas. An assessment was made of the dynamics of development of the grain production industry, trends of changes over 5 years, parameters of the influence and dependence of the yield of grain and leguminous crops on the level of fertilizer application were identified, clusters were identified that reflect the differentiation of municipal areas in grain production.