2010
DOI: 10.1016/j.bmc.2010.04.018
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Self-association of cyclic oligonucleotides through G:T:G:T minor groove tetrads

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Cited by 10 publications
(12 citation statements)
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References 47 publications
(44 reference statements)
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“…These experimental data are consistent with an intermolecular interaction of two guanines across the minor groove involving hydrogen bonding of one amino proton with the N3 of the opposite guanine. The resulting arrangement is a G:T:G:T tetrad, probably similar to minor groove G:T:G:T tetrads previously reported in the structures of some cyclic octamers (45) (Figure 5, right). In addition, other significant cross-peaks involving exchangeable protons clearly reveal the stacking of the G:T pairs over the hemi-protonated C:C + base pairs (H1G3(8)-H41/H42/H5C2(7) and H3T1(6)-H6/H5C2(7)), and also the stacking of the T4(9) residues over the G:T base pairs: H1G3(8)-MeT4(9) and H1G3(8)-H4′/H5′/H5″T4(9).…”
Section: Resultssupporting
confidence: 83%
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“…These experimental data are consistent with an intermolecular interaction of two guanines across the minor groove involving hydrogen bonding of one amino proton with the N3 of the opposite guanine. The resulting arrangement is a G:T:G:T tetrad, probably similar to minor groove G:T:G:T tetrads previously reported in the structures of some cyclic octamers (45) (Figure 5, right). In addition, other significant cross-peaks involving exchangeable protons clearly reveal the stacking of the G:T pairs over the hemi-protonated C:C + base pairs (H1G3(8)-H41/H42/H5C2(7) and H3T1(6)-H6/H5C2(7)), and also the stacking of the T4(9) residues over the G:T base pairs: H1G3(8)-MeT4(9) and H1G3(8)-H4′/H5′/H5″T4(9).…”
Section: Resultssupporting
confidence: 83%
“…Recently, we found that minor groove tetrads can also be formed by G:T mismatched base pairs (45), and we noticed that a similar minor groove G:T:G:T tetrad had previously been observed in the solution structures of oligonucleotides from the pyrimidine-rich strand of the centromeric protein B (CENP-B) box sequence (23,46,47). The CENP-B box is the conserved binding site for the centromeric protein CENP-B in mammalian centromeric satellite DNA (48,49).…”
Section: Introductionsupporting
confidence: 54%
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