2015
DOI: 10.1039/c5an00187k
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Self-calibrating highly sensitive dynamic capacitance sensor: towards rapid sensing and counting of particles in laminar flow systems

Abstract: In this report we propose a sensor architecture and a corresponding read-out technique on silicon for the detection of dynamic capacitance change. This approach can be applied to rapid particle counting and single particle sensing in a fluidic system. The sensing principle is based on capacitance variation of an interdigitated electrode (IDE) structure embedded in an oscillator circuit. The capacitance scaling of the IDE results in frequency modulation of the oscillator. A demodulator architecture is employed … Show more

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Cited by 18 publications
(21 citation statements)
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“…In order to increase the accuracy and sensitivity of the sensor, a new chip with a larger sensing area coverage (with wider IDC elements) was designed, as demonstrated in Figure 2 b. The details of the circuit design is available in our previous work [ 27 , 28 , 29 ].…”
Section: Methodsmentioning
confidence: 99%
“…In order to increase the accuracy and sensitivity of the sensor, a new chip with a larger sensing area coverage (with wider IDC elements) was designed, as demonstrated in Figure 2 b. The details of the circuit design is available in our previous work [ 27 , 28 , 29 ].…”
Section: Methodsmentioning
confidence: 99%
“…Our research group has worked on CMOS capacitive sensors operating in the frequency range of 5 GHz to 30 GHz for biological purposes [ 59 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. The sensing principle is based on the variation of capacitance embedded in a CMOS oscillator, causing a shift in the resonant frequency of the oscillator.…”
Section: Integrated Microwave Biosensormentioning
confidence: 99%
“…Such a noise analysis is extremely significant for complete system integration of such a sensor chip. Such a system integration approach was shown by our group, while integrating the CMOS sensor oscillator in a phase locked loop (PLL), in order to obtain a high sensitivity and a simpler output signal, as compared to the microwave output in the stand alone resonant frequency shift sensor [ 62 ]. The target of this work is to obtain an extremely sensitive sensor system with a reasonably easier to handle DC readout of the sensor.…”
Section: Integrated Microwave Biosensormentioning
confidence: 99%
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“…Modern lab-on-chip (LoC) platforms merge microfluidics with one or more functional and/or analytical components, which can include optics, microelectronics, microelectromechanical system (MEMS) and more [ 4 , 5 , 6 , 7 , 8 ]. Integrated microelectronic elements, for example, can handle varied tasks including (i) sensing via voltammetry, amperometry, capacitance, impedance spectroscopy; (ii) stimulation and actuation via applied current voltage, dielectrophoresis, field flow fractionation and electrowetting; (iii) data-acquisition and (iv) data treatment via digital signal processing elements [ 9 , 10 , 11 , 12 ], Some applications include gluco-sensors [ 13 ], breath alcohol measurements [ 14 ], integrated fuel cells, brain electrochemical monitor [ 15 ], droplet manipulation and sorting [ 16 ], and even imaging [ 17 ]. However, new approaches that integrate higher-level functionality are required to further propel LoCs platforms toward new applications.…”
Section: Introductionmentioning
confidence: 99%