Prompt disrobing and minimization of time to casualty decontamination are key to the effective treatment of individuals exposed to toxic chemicals. Established procedures for mass casualty decontamination that involve the deployment of equipment for showering with water (such as the ladder pipe system [LPS] and technical decontamination) necessarily introduce a short, but critical delay. The purpose of this study was to investigate the effectiveness of dry and wet decontamination approaches (individually and in combination) for removing a chemical warfare agent simulant from the hair and skin of human volunteers. A secondary aim was to quantify potential hazards arising from the decontamination processes. Volunteers were exposed to the simulant (mixture of methyl salicylate, fluorophore [curcumin] and mineral oil) as an aerosol within a custom-built dosing chamber. Three decontamination protocols (dry, LPS and technical decontamination) were applied in various sequences. The efficacy of the protocols was evaluated by whole-body fluorescent imaging and measurement of residual simulant recovered from the hair, skin, decontamination materials and air samples using liquid chromatography and thermal desorption gas chromatography. Dry decontamination before LPS or technical decontamination produced significant reductions in methyl salicylate skin contamination. The greatest reductions were seen with the Triple Protocol (dry, then LPS, then technical decontamination). Secondary sources of contamination (e.g. off-gassing of vapor and residue on wash cloths/towels) decreased following dry decontamination. The introduction of dry decontamination prior to wet forms of decontamination offers a simple strategy to initiate treatment at a much earlier opportunity, with a corresponding improvement in clinical outcomes. Our results confirm the value of a "Triple Protocol" response strategy based on the integration of dry and wet decontamination procedures. 3 Importantly, we highlight how these combined protocols may reduce toxicological risks downstream in the operational process.