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This paper addresses health care service delivery--its practice and its meanings--to a low income African-American population. Drawing on fieldwork and interviews at a sickle cell clinic, I explain why assumptions inCeleste, an African-American nurse-practitioner, is teaching Jamika, a sixteen year old with sickle cell anemia, how to self-administer a medication called Desferal. The procedure is quite complicated. Jamika has to insert a needle under the skin of her stomach, making sure it achieves the right angle and depth. Attached to the needle is a small cartridge of medicine which slowly, over the course of eight hours, will filter into her system and remove the iron that builds up in her blood as a result of her treatment for sickle cell anemia. She will use her Desferal equipment every other night at home while she sleeps. Celeste has a big notebook filled with pictures, diagrams, and charts to help her explain Desferal therapy to Jamika. They flip through the notebook together. "These symptoms mean too much Desferal, and these symptoms mean too much iron," Celeste explains, pointing to a chart. They speak for forty-five minutes, discussing Jamika's iron levels and other medications in very technical terms. They also discuss the different ways Jamika can integrate this therapy into her life with a minimum of discomfort, inconvenience Direct correspondence to