In this chapter, we have focused on the use of self-cleaning coating or surfaces which have more concerning the field of research due to the rising demand for self-disinfected and hygienic surfaces. Self-cleaning coatings can be used in automobile windshields, textiles, antifouling membranes, paints, building construction material, optoelectronic devices like solar panels, and in the medical aids and food industry. This chapter gives an outlook on nano TiO2-based superhydrophilic self-cleaning surfaces. The mechanism of superhydrophilicity of nano TiO2-based systems and photocatalytic properties are cautiously investigated. The photocatalytic behavior and superhydrophilicity of TiO2 are based on the photogenerated electron–hole pair. This chapter gives a general idea of a variety of systems and methods that could improve the self-cleaning behavior of TiO2 in the solar spectrum in view of the fact that TiO2 is only ultraviolet responsive. Evidences have indicated that the superhydrophilic wetting and antifogging performance are affected by porosity and surface hydroxyl (-OH) contents. In this chapter, the effect of multilayer assembly and the role of cumulative concentration of –OH groups on photocatalytic behavior is also discussed.