Self-Collection Tools for Routine Cervical Cancer Screening: A Review

Othman, Nor Hayati; Zaki, Fatma Hariati Mohamad

doi:10.7314/apjcp.2014.15.20.8563

Cited by 14 publications

(15 citation statements)

References 47 publications

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“…Unlike plasma, CVF does not contact many other tissues, and its volume is limited (milliliters versus liters). Moreover, the liquid can easily be collected by self-sampling in a non-invasive way using devices for lavages [ 36 , 66 ], or using tampons [ 38 , 67 ] (self-sampling devices developed before 2014 were reviewed in Othman et al [ 68 ]). Therefore, self-sampling of CVF could overcome the practical (e.g., busy schedule, transport, and distance), emotional (e.g., fear of pain and embarrassment), and cognitive (e.g., low perceived risk and absence of symptoms) barriers that some women experience in attending cervical cancer screening programs [ 69 – 71 ].…”

Section: Cervical Cancer and The Need For A Bedside Assaymentioning

confidence: 99%

Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer

Ostade

Dom

Tjalma

et al. 2017

Arch Gynecol Obstet

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PurposeDespite improvement in vaccines against human papilloma virus (HPV), the causative agent of cervical cancer, screening women for cervical precancer will remain indispensable in the coming 30–40 years. A simple test that could be performed at home or at a doctor’s practice and that informs the woman whether she is at risk would significantly help make a broader group of patients who aware that they need medical treatment. Cervical vaginal fluid (CVF) is a body fluid that is very well suited for such a test.MethodsNarrative review of cervical (pre)cancer candidate biomarkers from cervicovaginal fluid, is based on a detailed review of the literature. We will also discuss the possibilities that these biomarkers create for the development of a self-test or point-of-care test for cervical (pre)cancer.ResultsSeveral DNA, DNA methylation, miRNA, and protein biomarkers were identified in the cervical vaginal fluid; however, not all of these biomarkers are suited for development of a simple diagnostic assay.ConclusionsProteins, especially alpha-actinin-4, are most suited for development of a simple assay for cervical (pre)cancer. Accuracy of the test could further be improved by combination of several proteins or by combination with a new type of biomarker, e.g., originating from the cervicovaginal microbiome or metabolome.

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Section: Cervical Cancer and The Need For A Bedside Assaymentioning

confidence: 99%

Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer

Ostade

Dom

Tjalma

et al. 2017

Arch Gynecol Obstet

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“…According to these reasons, cervical cancer remains as a serious health problem in the world. In developing countries, which do not have screening programs, cervical cancer is one of the obvious causes of mortality (Othman et al, 2014). However, this cancer is known as a preventable cancer because it has one long pre-invasion step and available cytology screening programs (Monsonego et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitudes and Practice about Pap Smear Test among Women Living in Bojnourd, North East of Iran: a Population-Based Study

Bahri¹,

Jajvandian²,

Bolandhemmat³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The aim of the study was to assess the extent of knowledge, attitudes and practical behavior of women in Bojnourd conerning the Pap smear test. Materials and Methods: This cross-sectional and populationbased study was conducted with 1000 Iranian women aged 15-60 years old in Bojnourd city. In order to collect the data, a validated questionnaire was provided in four sections covering demographic information and questions about knowledge, attitude and practice about the Pap smear. Statistical analysis was performed with the Statistical Package for Social Sciences (version 17.0) applying a 0.05 significance level. Results: Evaluation of knowledge showed that 146 women (14.6%) had very weak, and 594 women (59.4%) had weak knowledge. In contrast, most of the women studied, 873 (87.3%), had a positive attitude toward the Pap smear test. According to the findings, 375 women (37.6%) had done this test so far. Findings indicated that the extent of knowledge had a meaningful relationship with the attitude status (p<0.0001). Also, there was a meaningful relationship between knowledge and practice, so that the weakest practice was seen in women who had weak knowledge (61.1%), (p<0.0001). Conclusions: According to findings of this research, most women do not have an appropriate knowledge about the necessity of having the Pap smear test, so that only a low percentage of women had undergone this test.

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“…It was previously shown that self-sampling using the Fournier-sampler on 292 subjects was not clinically acceptable due to lower sensitivity (41%) in sampling collection compared with conventional physician-obtained sampling (Aziz et al, 2013). It was previously shown that different methods of self-sampling obtain various amounts of cell mixture comprising more vaginal cells and less endocervical cells (Othman and Zaki, 2014). Another reason that might contribute to the difference in sample collection between self-sampling technique and physician-obtained sampling methods might be due to the existence of postmenopausal subjects.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Reliability of a Novel Self-sampling Device for Performing Cervical Sampling in Malaysia

Latiff

Rahman

Wee

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The participation of women in cervical cancer screening in Malaysia is low. Self-sampling might be able to overcome this problem.The aim of this study was to assess the reliability of self-sampling for cervical smear in our country. Materials and Methods: This cross-sectional study was conducted on 258 community dwelling women from urban and rural settings who participated in health campaigns. In order to reduce the sampling bias, half of the study population performed the self-sampling prior to the physician sampling while the other half performed the self-sampling after the physician sampling, randomly. Acquired samples were assessed for cytological changes as well as HPV DNA detection. Results: The mean age of the subjects was 40.4±11.3 years. The prevalence of abnormal cervical changes was 2.7%. High risk and low risk HPV genotypes were found in 4.0% and 2.7% of the subjects, respectively. A substantial agreement was observed between self-sampling and the physician obtained sampling in cytological diagnosis (k=0.62, 95%CI=0.50, 0.74), micro-organism detection (k=0.77, 95%CI=0.66, 0.88) and detection of hormonal status (k=0.75, 95%CI=0.65, 0.85) as well as detection of high risk (k=0.77, 95%CI=0.4, 0.98) and low risk (K=0.77, 95%CI=0.50, 0.92) HPV. Menopausal state was found to be related with 8.39 times more adequate cell specimens for cytology but 0.13 times less adequate cell specimens for virological assessment. Conclusions: This study revealed that self-sampling has a good agreement with physician sampling in detecting HPV genotypes. Self-sampling can serve as a tool in HPV screening while it may be useful in detecting cytological abnormalities in Malaysia.

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Self-Collection Tools for Routine Cervical Cancer Screening: A Review

Cited by 14 publications

References 47 publications

Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer

Candidate biomarkers in the cervical vaginal fluid for the (self-)diagnosis of cervical precancer

Knowledge, Attitudes and Practice about Pap Smear Test among Women Living in Bojnourd, North East of Iran: a Population-Based Study

Assessment of the Reliability of a Novel Self-sampling Device for Performing Cervical Sampling in Malaysia

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