Fiber optic sensors have matured to allow the detection of chemical and physical parameters at multiple points, or in a distributed fashion, along the length of a single optical fiber strand. The electro-optic readout unit connected to the fiber needs to be tailored to the specific sensor application to balance the requirements for spatial and frequency resolution, interrogation intervals, readout time, noise suppression, system size and cost, and other parameters. This paper will discuss different fiber optic sensor configurations and suitable readout strategies to meet the requirements of the sensing application.