Self-consistent field modeling of mesomorphic phase changes of monoolein and phospholipids in response to additives

Lange, Niek de; Kleijn, J. Mieke; Leermakers, F.A.M.

doi:10.1039/d1cp00697e

Cited by 5 publications

(6 citation statements)

References 75 publications

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“…The free energy of the system is then minimized using an iterative scheme, yielding the partition function of the polymers and subsequently giving the equilibrium volume fractions at each lattice layer z . The SF-SCF calculations slightly depend on the lattice chosen 40 and one may choose to use a different lattice parameter. However, the equations presented must then be adjusted, as the transition probabilities and the relation between the Kuhn length and the forward probabilities are dependent on the lattice parameter.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

“…Phys., 2022, 24, 3618-3631 | 3621 lattice layer z. The SF-SCF calculations slightly depend on the lattice chosen 40 and one may choose to use a different lattice parameter. However, the equations presented must then be adjusted, as the transition probabilities and the relation between the Kuhn length and the forward probabilities are dependent on the lattice parameter.…”

Section: Pccp Papermentioning

confidence: 99%

See 1 more Smart Citation

The depletion thickness in solutions of semi-flexible polymers near colloidal surfaces: analytical approximations

Martens

Leuken

Opdam

et al. 2022

Phys. Chem. Chem. Phys.

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Section: Theoretical Backgroundmentioning

confidence: 99%

Section: Pccp Papermentioning

confidence: 99%

The depletion thickness in solutions of semi-flexible polymers near colloidal surfaces: analytical approximations

Martens

Leuken

Opdam

et al. 2022

Phys. Chem. Chem. Phys.

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“…This results in smaller packing parameters (Supporting Information, Table S3 ), favoring lower-curvature phases when combined with MO, as modeled with similar neutral (but non-light responsive) surfactants. 55 On decreasing the alkyl chain length from C 8 AzoC 8 E 4 to C 6 AzoC 4 E 4 , there is a transition from the zero-curvature lamellar phase to the inverse hexagonal phase, with a higher negative curvature. This shows that the AzoPS chain length dominates the packing and spontaneous curvature of the amphiphile bilayer.…”

Section: Resultsmentioning

confidence: 98%

“…Compared to MO, the AzoPS have a much larger head group areas, due to the four ethylene glycol groups, and also longer tail lengths. This results in smaller packing parameters (Supporting Information, Table S3), favoring lower-curvature phases when combined with MO, as modeled with similar neutral (but non-light responsive) surfactants . On decreasing the alkyl chain length from C 8 AzoC 8 E 4 to C 6 AzoC 4 E 4 , there is a transition from the zero-curvature lamellar phase to the inverse hexagonal phase, with a higher negative curvature.…”

Section: Resultsmentioning

confidence: 99%

Light-Responsive Molecular Release from Cubosomes Using Swell-Squeeze Lattice Control

et al. 2022

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Stimuli-responsive materials are crucial to advance controlled delivery systems for drugs and catalysts. Lyotropic liquid crystals (LLCs) have well-defined internal structures suitable to entrap small molecules and can be broken up into low-viscosity dispersions, aiding their application as delivery systems. In this work, we demonstrate the first example of light-responsive cubic LLC dispersions, or cubosomes, using photoswitchable amphiphiles to enable external control over the LLC structure and subsequent on-demand release of entrapped guest molecules. Azobenzene photosurfactants (AzoPS), containing a neutral tetraethylene glycol head group and azobenzene-alkyl tail, are combined (from 10−30 wt %) into monoolein-water systems to create LLC phases. Homogenization of the bulk LLC forms dispersions of particles, ∼200 nm in diameter with internal bicontinuous primitive cubic phases, as seen using small-angle X-ray scattering and cryo-transmission electron microscopy. Notably, increasing the AzoPS concentration leads to swelling of the cubic lattice, offering a method to tune the internal nanoscale structure. Upon UV irradiation, AzoPS within the cubosomes isomerizes within seconds, which in turn leads to squeezing of the cubic lattice and a decrease in the lattice parameter. This squeeze mechanism was successfully harnessed to enable phototriggerable release of trapped Nile Red guest molecules from the cubosome structure in minutes. The ability to control the internal structure of LLC dispersions using light, and the dramatic effect this has on the retention of entrapped molecules, suggests that these systems may have huge potential for the next-generation of nanodelivery.

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“…Hence, monoolein bulk phases comprise long-range water labyrinths cloistered between bicontinuous lipid bilayers displaying specific curvatures. In this way, cubic phases may be produced in lipid/water systems in the regions lying between the transition of the liquid crystalline lamellar phase and the inverse hexagonal H II phase, and they usually take place in narrow ranges of temperature and/or a strict proportion of components [ 46 , 47 , 48 ]. In excess water and room-temperature monoolein, with its cone-like molecular shape, assembles as a bulk phase of Pn3m cubic symmetry, which by turn, can transition to new symmetries in the presence of additives, such as other lipids of specific molecular shapes and different critical packing parameters [ 45 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Flavonoid-Labeled Biopolymer in the Structure of Lipid Membranes to Improve the Applicability of Antioxidant Nanovesicles

Mathews,

Gama,

Megiati

et al. 2024

Pharmaceutics

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Nanovesicles produced with lipids and polymers are promising devices for drug and bioactive delivery and are of great interest in pharmaceutical applications. These nanovesicles can be engineered for improvement in bioavailability, patient compliance or to provide modified release or enhanced delivery. However, their applicability strongly depends on the safety and low immunogenicity of the components. Despite this, the use of unsaturated lipids in nanovesicles, which degrade following oxidation processes during storage and especially during the proper routes of administration in the human body, may yield toxic degradation products. In this study, we used a biopolymer (chitosan) labeled with flavonoid (catechin) as a component over a lipid bilayer for micro- and nanovesicles and characterized the structure of these vesicles in oxidation media. The purpose of this was to evaluate the in situ effect of the antioxidant in three different vesicular systems of medium, low and high membrane curvature. Liposomes and giant vesicles were produced with the phospholipids DOPC and POPC, and crystalline cubic phase with monoolein/DOPC. Concentrations of chitosan–catechin (CHCa) were included in all the vesicles and they were challenged in oxidant media. The cytotoxicity analysis using the MTT assay (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) revealed that concentrations of CHCa below 6.67 µM are non-toxic to HeLa cells. The size and zeta potential of the liposomes evidenced the degradation of their structures, which was minimized by CHCa. Similarly, the membrane of the giant vesicle, which rapidly deteriorated in oxidative solution, was protected in the presence of CHCa. The production of a lipid/CHCa composite cubic phase revealed a specific cubic topology in small-angle X-ray scattering, which was preserved in strong oxidative media. This study demonstrates the specific physicochemical characteristics introduced in the vesicular systems related to the antioxidant CHCa biopolymer, representing a platform for the improvement of composite nanovesicle applicability.

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Self-consistent field modeling of mesomorphic phase changes of monoolein and phospholipids in response to additives

Abstract: Mapping the topological phase behaviour of lipids in aqueous solution is time consuming and finding the ideal lipid system for a desired application is often a matter of trial and...

Cited by 5 publications

References 75 publications

The depletion thickness in solutions of semi-flexible polymers near colloidal surfaces: analytical approximations

The depletion thickness in solutions of semi-flexible polymers near colloidal surfaces: analytical approximations

Light-Responsive Molecular Release from Cubosomes Using Swell-Squeeze Lattice Control

Flavonoid-Labeled Biopolymer in the Structure of Lipid Membranes to Improve the Applicability of Antioxidant Nanovesicles

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