Self-defensive antibacterial layer-by-layer hydrogel coatings with pH-triggered hydrophobicity

Lu, Yiming; Wu, Yong; Liang, Jenn‐Tai; Libera, Matthew; Sukhishvili, Svetlana A.

doi:10.1016/j.biomaterials.2014.12.048

Cited by 141 publications

(105 citation statements)

References 39 publications

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“…Then the cell membranes are disrupted to cause cell lysis in different ways, for example, polymeric spacer effect, phospholipid sponge effect, and extraction of stabilizing ions, which was also supported by new results . However the surface coated with layer‐by‐layer of poly (ethyl or propyl or butyl acrylic acid) and polyvinylpyrrolidone killed bacteria through disruption of the cell membranes with hydrophobic alkyl chains without electrostatic interaction …”

Section: Introductionmentioning

confidence: 79%

Developments in antimicrobial polymers

Ren

Cheng

Wang

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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Effective antimicrobial polymers have been attracting more interests because of the low propensity to cause drug‐resistant microorganisms. The recent progresses in antimicrobial polymers are updated according to the action approaches, that is, antimicrobial polymers with free mobility or fixed on surfaces, respectively. Free antimicrobial polymers kill pathogens majorly via electrostatic interaction followed by disruption of the cell membranes; strong antimicrobial activity of primary/secondary amines, new chemical units, and peptides without facial amphiphilicity are highlighted; and the dependences on amphiphilicity, topology, and self‐assembly profiles are summarized. Antimicrobial polymers fixed on surfaces kill pathogens via interaction with the cell membranes of pathogens via electrostatic or hydrophobic interaction; approaches to antimicrobial surfaces based on covalently grafting, anchoring, and bulk‐mixing of polymers are summarized; and new designs of sustainable antimicrobial surfaces and hydrogels are highlighted. Deep biology understanding and development strategies of materials are suggested for the future. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 632–639

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Section: Introductionmentioning

confidence: 79%

Developments in antimicrobial polymers

Ren

Cheng

Wang

et al. 2016

J. Polym. Sci. Part A: Polym. Chem.

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“…For those floating bacteria, they will be powerless. Thus, some other strategies, like self‐defensive surface coating, have been developed via a layer‐by‐layer method . In general, this strategy is featured by the application of electrostatic attractions or hydrogen bonding to form the thin layer coating on a surface.…”

Section: Antimicrobial Systemsmentioning

confidence: 99%

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Liu

et al. 2019

Macromolecular Bioscience

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Bacterial infection is becoming the biggest threat to human health. The scenario is partly due to the ineffectiveness of the conventional antibiotic treatments against the emergence of multidrug‐resistant bacteria and partly due to the bacteria living in biofilms or cells. Adaptive biomaterials can change their physicochemical properties in the microenvironment of bacterial infection, thereby facilitating either their interactions with bacteria or drug release. The trends in treating bacterial infections using adaptive biomaterials‐based systems are flourishing and generate innumerous possibility to design novel antimicrobial therapeutics. This feature article aims to summarize the recent developments in the formulations, mechanisms, and advances of adaptive materials in bacterial infection diagnosis, contact killing of bacteria, and antimicrobial drug delivery. Also, the challenges and limitations of current antimicrobial treatments based on adaptive materials and their clinical and industrial future prospects are discussed.

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“…A variety of other innovative polymers have been developed as antimicrobial coatings such as hydrogels with a pH-triggered hydrophobicity. 46 The coatings comprised several hydrogel poly(2-alkylacrylic acid) films with different hydrophobicities (i.e. polymethacrylic acid, poly(2-ethylacrylic acid), poly(2-n-propylacrylic acid), and poly(2-n-butylacrylic acid)).…”

Section: Polymer-based Coatingsmentioning

confidence: 99%

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

Cyphert

Recum

2017

Exp Biol Med (Maywood)

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This work provides an overview, with advantages and limitations of the most recently developed antibacterial coating technologies, enabling other researchers in the field to more easily determine which technology is most advantageous for them to further develop and pursue. AbstractOver the past 20 years, the field of antimicrobial medical device coatings has expanded nearly 30-fold with technologies shifting their focus from diffusion-only based (short-term antimicrobial eluting) coatings to long-term antimicrobial eluting and intrinsically antimicrobial functioning materials. A variety of emergent coatings have been developed with the goal of achieving long-term antimicrobial activity in order to mitigate the risk of implanted device failure. Specifically, the coatings can be grouped into two categories: those that use antibiotics in conjunction with a polymer coating and those that rely on the intrinsic properties of the material to kill or repel bacteria that come into contact with the surface. This review covers both long-term drug-eluting and non-eluting coatings and evaluates the inherent advantages and disadvantages of each type while providing an overview of variety applications that the coatings have been utilized in.

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Self-defensive antibacterial layer-by-layer hydrogel coatings with pH-triggered hydrophobicity

Cited by 141 publications

References 39 publications

Developments in antimicrobial polymers

Developments in antimicrobial polymers

Recent Advances and Future Prospects on Adaptive Biomaterials for Antimicrobial Applications

Emerging technologies for long-term antimicrobial device coatings: advantages and limitations

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