Self-dissolving micropile array tips for percutaneous administration of insulin

Ito, Yoshiaki; Yamazaki, Takenao; Sugioka, Nobuyuki; Takada, Kanji

doi:10.1007/s10856-009-3923-x

Cited by 33 publications

(14 citation statements)

References 16 publications

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“…delivery of molecules across the skin is overcoming the stratum corneum barrier. Thus, a number of enhancement methods have been proposed and investigated to improve bioavailability of peptides/proteins administered transdermally, including chemical, electrical and physical methods such as penetration enhancers (25), drug carriers such as transfersomes (30) or biphasic lipid vesicles (31), iontophoresis (6,27), ultrasound (8,28), MNs (26,29,34,36), electroporation (7), thermal ablation (9) or radiofrequency ablation (32).…”

Section: Discussionmentioning

confidence: 99%

Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery

et al. 2011

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“…38) The microconduits disappeared within 2 h macroscopically as well as our previous report. 39) In addition, the shape of SDMP was conical and the tops of the SDMP array were very narrow, approximately 10 mm. Therefore, after the insertion of SDMP array into the skin where SDMP encountered the environmental water, hydration and dissolution occurred.…”

Section: )mentioning

confidence: 99%

Permeation Enhancement of Ascorbic Acid by Self-Dissolving Micropile Array Tip through Rat Skin

Ito¹,

Maeda²,

Fukushima³

et al. 2010

Chem. Pharm. Bull.

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Ascorbic acid (AA, vitamin C) is a hydrophilic vitamin that cannot be produced endogenously in rats and primates including human and is widely used for the protection of the aging of the skin due to the exposure to the UV light and for the acceleration of the synthesis of collagen in the skin. [1][2][3][4] AA was shown to be absorbed from the gastrointestinal tract by an active transport system, though limited amount of AA was transported by this system. 5) In addition, after AA was absorbed, AA was rapidly eliminated from the body by the oxidative metabolism through both enzymatic and nonenzymatic processes.2) Therefore, even if we intake excess amount of AA, sufficient amount of AA is not absorbed into the systemic circulation and is not delivered to its target tissue, skin.2) To conquer this problem, percutaneous delivery of AA has been challenged. The advantage of percutaneous delivery of AA is (1) to obtain high concentration of AA in the skin and (2) to escape the hepatic first-pass effect before reaching to the systemic circulation. However, when AA is percutaneously administered, the penetration of AA to the dermal tissue is difficult because of the high barrier function of the skin. To increase the permeability of AA, derivatives such asascorbic acid 2-sulfate 8) and disodium isostearyl 2-o-L-ascorbyl phosphate, 9,10) has been developed. Also Gopinath et al. designed ascorbyl palmitate vesicles (Aspasomes) for the transdermal delivery of ascorbic acid.11) Furthermore, recent advances in pharmaceutical technology have promoted the research on the permeability enhancement of AA using physical absorption enhancing method like iontophoresis 12) and microemulsion technologies.11,13) Iontophoresis uses an electric field to drive ionized molecules across the skin by electrophoresis and non-ionized molecules by electro osmosis. 14)Despite concerns about skin irritation, iontophoresis may be useful to deliver some peptides and small proteins.15) On the other hand, microneedles are also one of the physical methods for the percutaneous absorption of drugs. With microneedles, small microconduits are formed on the skin. Recent advance in microfabrication technology has made it possible to prepare microneedles that have a possibility of novel transdermal drug delivery system (TDDS). Since the first publication by Henry et al.,16) microfabrication techniques for the production of silicon, metal, glass and polymer microneedle arrays with micrometer dimensions have been developed. 17-20) The microneedles are either solid or hollow and posses a geometrical shape. Microneedle TDDS is roughly defined by a micron size needle preparation for percutaneous administration. Microneedle TDDSs are classified as follows; (1) extremely small needle through which drug solution can be injected into the skin, (2) metallic and/or silastic microneedles on which surface drug is coated, and (3) metallic and/or silastic microneedles by which microconduits are made on the skin and drug solution is applied after removing the microneedles. H...

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“…It should be noted that during SH-DM preparation, the mold covered with the mixture was vacuumized in a vacuum oven at 160 ± 0.5 C under a pressure of 70 kPa for 1 min. Due to the limitation of the conventional casting method, such as the pore formation leads to loss of mechanical strength and microneedle arrays incomplete, the method of drying and degassing under pressure has been applied to obtain the microneedles with complete shape and sufficient mechanical strength 50,51 .…”

Section: Resultsmentioning

confidence: 99%

Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits

Chen

Shen

et al. 2015

Pharmaceutical Development and Technology

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Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.

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Self-dissolving micropile array tips for percutaneous administration of insulin

Cited by 33 publications

References 16 publications

Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery

Laser-Engineered Dissolving Microneedle Arrays for Transdermal Macromolecular Drug Delivery

Permeation Enhancement of Ascorbic Acid by Self-Dissolving Micropile Array Tip through Rat Skin

Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits

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