<p style='text-indent:20px;'>Hermitian self-orthogonal codes form an essential ingredient in the construction of quantum stabilizer codes. In this paper, we present two new classes of Hermitian self-orthogonal MDS codes from twisted generalized Reed-Solomon codes. The constructed codes are monomially inequivalent to generalized Reed-Solomon codes. Two new classes of Hermitian LCD MDS codes can then be derived. Finally, based on the constructed Hermitian self-orthogonal MDS codes, we present two classes of quantum MDS codes with new parameters.</p>