Self-efficacy, quality of life, and weight loss in overweight/obese endometrial cancer survivors (SUCCEED): A randomized controlled trial

McCarroll, Michele L.; Armbruster, Shannon D.; Frasure, Heidi E.; Gothard, M. David; Gil, Karen M.; Kavanagh, Mary; Waggoner, Steven; Gruenigen, Vivian E. von

doi:10.1016/j.ygyno.2013.12.023

Cited by 93 publications

(66 citation statements)

References 25 publications

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“…The two trials in endometrial cancer survivors are summarized in Table 1. The Survivors of Uterine Cancer Empowered by Exercise and Health Diet (SUCCEED) trial 40 randomly assigned 75 overweight and obese women with stage I or II endometrial cancer (on average 20.7 months postdiagnosis) to a 12-month intervention or usual care. The intervention was delivered primarily via group face-to-face sessions in the first 6 months, with support provided via newsletters and telephone/e-mail in the second 6 months.…”

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confidence: 99%

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Weight Loss Randomized Intervention Trials in Female Cancer Survivors

Chlebowski

Reeves

2016

JCO

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Observational study evidence has associated overweight/obesity with decreased survival in women with breast cancer and with several other cancers. Although full-scale, definitive weight loss adjuvant intervention trials with cancer end points remain to be conducted, a number of randomized controlled trials have evaluated weight loss interventions in survivors of cancer in women. Findings from these trials in breast, endometrial, and ovarian cancer are reviewed. MethodsA systematic review of randomized controlled clinical trials evaluating weight loss interventions was updated (for studies published 2013 to 2016), and clinical trials registers were searched for ongoing trials. ResultsSix new randomized trials in breast cancer survivors and two randomized trials in endometrial cancer survivors were identified. Evidence from these trials and the 10 earlier randomized trials in female cancer survivors provide support for the feasibility of recruiting women closer to the cancer diagnosis and efficacy for achieving weight loss, in particular with telephone-based interventions, and have identified the challenge of achieving significant weight loss in African American cancer survivors and of maintaining weight loss in any cancer survivor group. Seven ongoing randomized trials are evaluating the influence of weight loss interventions on cancer end points (five in breast cancer, one in ovarian cancer, and one in endometrial cancer). ConclusionAfter a decade of preliminary studies, ongoing randomized, controlled clinical trials will potentially provide definitive assessment of whether weight loss can improve breast cancer clinical outcome. Longer-term interventions (. 2 years' duration) may be needed to optimize weight loss maintenance and any potential benefits on cancer end points.

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“…40 Haggerty and colleagues 41 recruited 16 women (BMI . 30 kg/m 2 ) with stage I to III endometrial cancer and four women with endometrial hyperplasia, who were randomly assigned to one of two weight loss interventions.…”

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Weight Loss Randomized Intervention Trials in Female Cancer Survivors

Chlebowski

Reeves

2016

JCO

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“…Reductions in BMI may decrease the number of comorbidities and related negative health factors that Black women experience. Weight loss and exercise programs have not been well-studied in patients prior to hysterectomy, but have been studied among the endometrial cancer survivor population [26–28]. …”

Section: Discussionmentioning

confidence: 99%

“…Weight loss through changes in diet and increased physical activity has been shown to be achievable for endometrial cancer survivors[26–28] and endometrial cancer survivors show strong desire to participate in exercise interventions[30]. Studies in functional decline for other conditions have shown that a lack of regular vigorous physical activity nearly doubled the odds of further declines over time, and suggests that physical activity can reduce potential declines by as much as 32%[15].…”

Section: Discussionmentioning

confidence: 99%

Race-based disparities in loss of functional independence after hysterectomy for uterine cancer

Dean

Zhang

Latif

et al. 2016

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Purpose Racial disparities in uterine cancer-related outcomes have been reported. The goal of this study was to determine if race, pre-operative body mass index (BMI) and medical comorbidities are predictors of loss of functional independence after surgery for uterine cancer. Methods Loss of independence was defined as a change from pre-operative functional independence, to a post-operative requirement of discharge to a post-care facility or death within the first 30 days following uterine cancer surgery. Demographic factors, comorbidities, BMI, intra-operative and post-operative outcomes and discharge status were abstracted from the 2011 and 2012 American College of Surgeons National Surgical Quality Improvement Program (NSQIP). Statistical analyses included multivariable logistic regression and Wald tests for interaction. Results 4,005 patients had uterine cancer and were functionally independent pre-operatively. After adjusting for clinical features and comorbidities, Black women were not significantly more likely to lose functional independence than non-Black women. However, a significant interaction (OR=1.17, p<0.001) was found between race and BMI for loss of functional independence. Interaction plots revealed worsening functional outcomes for Black women with BMI>40 but not in non-Blacks. Conclusions The interaction suggests a 17% increased odds of losing independence for each unit of BMI difference for Black uterine cancer patients, or 170% increased odds of losing independence for a 10-point increase in BMI, given a linear association. To reduce the likelihood of losing post-operative functional independence, Black, high BMI patients with or at-risk for uterine cancer may especially benefit from weight loss or interventions to optimize physical function.

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“…An intervention focused on diet as well as physical activity was reported on by Vivian von Gruenigen, MD, motivated by reports that only 1% of endometrial cancer survivors meet 2006 ACS guidelines for cancer survivors [33]. In the randomized SUCCEED study, the intervention group showed improvements in physical activity, kilocalories consumed, and fruit and vegetable servings, as well as weight loss [34]. Self-efficacy was an important factor in achieving positive results.…”

Section: Quality Of Lifementioning

confidence: 99%