Self-emulsifying drug delivery systems: a novel approach to deliver drugs

Abstract

Self-emulsifying drug delivery systems (SEDDS) are a proven method for poorly soluble substances works by increasing the solubility and bioavailability. SEDDS and isotropic mixtures, are composed of oils, surfactants, and occasionally cosolvents. The ability of these formulations and methods to produce microemulsions or fine oil-in-water (o/w) emulsions after moderate stirring and dilution by water phase along the GI tract might be a promising technique for lipophilic agents with dissolution rate-limited absorption. This review provides an outline of SEDDS's numerous advances and biopharmaceutical elements, types, manufacturing, characterization, limitations, and future prospects. The evaluation of SEDDS and its applications are also discussed, focusing on the advances of SEDDS's solid self-emulsifying delivery mechanism and dosage form. By integrating suitable polymer into the formulation, SEDDS may be studied for the creation of a formulation with sustained drug release. This technology's improvement might lead to a new application in the field of medicine delivery. SEDDS has been demonstrated to be quite efficient in increasing oral bioavailability of lipophilic products. SEDDS is one of the promising methods for controlling the characteristics of medications that are not great choices for oral delivery. It is also worth mentioning that SEDDS may be made in variety of solid dosage forms that are acceptable for both oral and parenteral administration.

Development of Squalene-Based Oil-in-Water Emulsion Adjuvants Using a Self-Emulsifying Drug Delivery System for Enhanced Antigen-Specific Antibody Titers

“… 30–32 SEDDS has been used for designing formulations to improve the oral absorption of highly hydrophobic drugs. 33 , 34 Here, we used SEDDS technique to formulate squalene-based oil-in-water emulsions as the adjuvant.…”

“…[30][31][32] SEDDS has been used for designing formulations to improve the oral absorption of highly hydrophobic drugs. 33,34 Here, we used SEDDS technique to formulate squalene-based oil-in-water emulsions as the adjuvant. MF59 ® , a famous squalene-based adjuvant, is an oil-in-water emulsion containing squalene (4.3%) in citric acid buffer with stabilizing nonionic surfactants, Tween 80 (0.5%) and Span ® 85 (0.5%).…”

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

“…Self-emulsifying drug delivery system (SEDDS) is a homogeneous mixture of drugs, co-emulsifiers, hydrophilic emulsifiers, and oil phase, which can spontaneously form O/W emulsion or microemulsion under gastrointestinal peristalsis or mild stirring in ambient temperature, but it has some defects such as instability and large gastrointestinal irritation (Salawi, 2022 ). However, the solid self-emulsifying drug delivery system (S-SMEDDS) can well overcome these defects (C Sun et al., 2018 ).…”

Approaches to Improve bioavailability and oral absorption of low water-soluble drug by self- emulsifying drug delivery system

“…SEDDS is a Novel formulation employed to increase solubility and consequently the bioavailability of poorly water soluble drugs such as BCS Class-II drug include Bilastine, Vitamin-E, monoxidil, posoconazole, etoricoxib, safinamide, eltrombopag olamine, brexpiprazole, ketoprofen, indomethacin and hydrocortisone. The BCS Class-II Drugs exhibit poor aqueous solubility, which affects their low bioavailability, variable absorption after oral delivery [1]. There are formulations strategies have been described to increase the dissolution rate of drugs by reducing their particle size (agitation, high energy approach) and salt formation, using excipient such as lipids surfactants, co-surfactant, and cyclodextrins for SEDDS based formulation.…”