Self-etching adhesives: possible new pulp capping agents to vital pulp therapy

Abstract

Pulp capping is one of the solving for keeping vital pulp in the case of dentin caries, reversible pulpitis or traumatic pulp exposure. The presence of bacteria on the cavity walls or in the pulp was the major factor that leads to the failure of pulp capping. Traditional pulp capping agent, calcium hydroxide, may not prevent microleakage. Selfetching system is a newly developed adhesive system, which could provide less microleakage and would not break down or dissolve, preventing the oral fluids and bacteria from the pulp along the cavity wall. This may reduce such clinical problems as postoperative sensitivity, secondary caries and marginal discoloration. Researches showed that some kinds of self-etching adhesives induced the mild to moderate inflammatory pulp response, with negative bacterial staining. Inclusion of antibacterial components into self-etching system, such as 12-methacryloyloxydodecylpyridinium bromide (MDPB) may inhibit bacteria and provide better clinical effects. It is speculated that using the self-etching adhesive system containing the antibacterial agent, such as MDPB, to the dental pulp directly or indirectly, may inhibit bacteria after the placement of restoration as well as residual bacteria in the cavity.

Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria

“…Suppression of bacterial activity is considered a key modality in controlling dental caries and periodontal diseases. Various strategies have been developed, including inhibition of protease activity [ 13 , 14 ] and the application of antibacterial dental materials [ 15 , 16 ]. Recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (S-PRG) filler was revealed [ 17 ].…”

Investigation of a Novel Injectable Chitosan Oligosaccharide—Bovine Hydroxyapatite Hybrid Dental Biocomposite for the Purposes of Conservative Pulp Therapy

“…This is less relevant for the placement of the material, as CPT is conducted under dental dam isolation, which reduces the potential for washing out the material during its placement [ 13 ]. However, the breakdown of the material over time within the pulp chamber could lead to microleaks in the absence of a good orifice barrier and permanent restoration [ 19 ]. Therefore, future studies may look at incorporating a crosslinking agent into the formulation to improve the structural integrity of the experimental pulp-capping material.…”

Pulp preservation in immature permanent teeth

“…Current investigations have also shown that even low concentrations of triethylene glycol dimethacrylate (TEGDMA), a compound found in dentin bonding agents, inhibits dental pulp cells from mineralization and reparative dentin formation . However, some promise has been shown using adhesive resins combined with additives (growth factors), including synthetic peptides derived from dental matrix protein, hydroxyapatite powder, calcium chloride (CaCl 2 ) , and antibacterial agents such as 12‐methacryloyloxydodecylpyridinium bromide (MDPB) . Although bonding agents do not promote a favorable environment for pulp repair and bridge formation, they can provide excellent seals when used in conjunction with composites for coronal restorations in vital pulp therapy.…”