Self-gated fetal cardiac MRI with tiny golden angle iGRASP: A feasibility study

Haris, Kostas; Hedström, Erik; Bidhult, Sebastian; Testud, Frederik; Maglaveras, Nicos; Heiberg, Einar; Hansson, Stefan R.; Arheden, Håkan; Aletras, Anthony H.

doi:10.1002/jmri.25599

Cited by 55 publications

(57 citation statements)

References 35 publications

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“…Its extension to tiny golden angle (tyGA) 24 enabled the translation of the GA principle to higher field strength and provided even larger flexibility in the selection of the number of projections used for reconstruction of a single frame (generalized Fibonacci sequence). The combination with sparse sense reconstruction (tyGRASP) has proven beneficial artifact properties for RT cardiac imaging 25–27 …”

Section: Introductionmentioning

confidence: 99%

Feasibility of real‐time cardiac MRI in mice using tiny golden angle radial sparse

Metze

Abaei

et al. 2020

NMR in Biomedicine

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Cardiovascular magnetic resonance imaging has proven valuable for the assessment of structural and functional cardiac abnormalities. Even although it is an established imaging method in small animals, the long acquisition times of gated or self-gated techniques still limit its widespread application. In this study, the application of tiny golden angle radial sparse MRI (tyGRASP) for real-time cardiac imaging was tested in 12 constitutive nexilin (Nexn) knock-out (KO) mice, both heterozygous (Het, N = 6) and wild-type (WT, N = 6), and the resulting functional parameters were compared with a well-established self-gating approach. Real-time images were reconstructed for different temporal resolutions of between 16.8 and 79.8 ms per image. The suggested approach was additionally tested for dobutamine stress and qualitative first-pass perfusion imaging. Measurements were repeated twice within 2 weeks for reproducibility assessment. In direct comparison with the high-quality, self-gated technique, the real-time approach did not show any significant differences in global function parameters for acquisition times below 50 ms (rest) and 31.5 ms (stress).Compared with WT, the end-diastolic volume (EDV) and end-systolic volume (ESV) were markedly higher (P < 0.05) and the ejection fraction (EF) was significantly lower in the Het Nexn-KO mice at rest (P < 0.001). For the stress investigation, a clear decrease of EDV and ESV, and an increase in EF, but maintained stroke volume, could be observed in both groups. Combined with ECG-triggering, tyGRASP provided firstpass perfusion data with a temporal resolution of one image per heartbeat, allowing the quantitative assessment of upslope curves in the blood-pool and myocardium.Excellent inter-study reproducibility was achieved in all the functional parameters.The tyGRASP is a valuable real-time MRI technique for mice, which significantly reduces the scan time in preclinical cardiac functional imaging, providing sufficient image quality for deriving accurate functional parameters, and has the potential to investigate real-time and beat-to-beat changes.

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Section: Introductionmentioning

confidence: 99%

Feasibility of real‐time cardiac MRI in mice using tiny golden angle radial sparse

Metze

Abaei

et al. 2020

NMR in Biomedicine

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“…Selection is however challenged by limited cardiovascular visualization by ultrasound or in particular diagnoses with a high rate of false positives (Matsui et al, 2008). Self-gated fetal cine cardiovascular magnetic resonance (CMR) imaging has enabled cine CMR for assessing fetal cardiac anatomy and function also in cases where ultrasound is insufficient for diagnosis (Lloyd et al, 2016;Roy et al, 2016;Chaptinel et al, 2017;Haris et al, 2017). One such solution (Haris et al, 2017) based on socalled iterative Golden-angle RAdial Sparse Parallel (iGRASP) MRI (Feng et al, 2014;Wundrak et al, 2016) was applied in the presented case showing how this CMR method can improve diagnostic accuracy and have direct impact on delivery planning.…”

Section: Case Reportmentioning

confidence: 99%

Fetal iGRASP cine CMR assisting in prenatal diagnosis of complicated cardiac malformation with impact on delivery planning

Bhat

Haris

Bidhult

et al. 2019

Clin Physio Funct Imaging

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SummaryLimited visualization of the fetal heart and vessels by fetal ultrasound due to suboptimal fetal position, patient habitus and skeletal calcification may lead to missed diagnosis, overdiagnosis and parental uncertainty. Counselling and delivery planning may in those cases also be tentative. The recent fetal cardiac magnetic resonance (CMR) reconstruction method utilizing tiny golden‐angle iGRASP (iterative Golden‐angle RAdial Sparse Parallel MRI) allows for cine imaging of the fetal heart for use in clinical practice. This case describes an unbalanced common atrioventricular canal where limited ultrasound image quality and visibility of the aortic arch precluded confirming or ruling out presence of a ventricular septal defect. Need of prostaglandins or neonatal intervention was thus uncertain. Cardiovascular magnetic resonance imaging confirmed ultrasound findings and added value by ruling out a significant ventricular septal defect and diagnosing arch hypoplasia. This confirmed the need of patient relocation for delivery at a paediatric cardiothoracic surgery centre and prostaglandins could be initiated before the standard postnatal ultrasound. The applied CMR method can thus improve diagnosis of complicated fetal cardiac malformation and has direct clinical impact.

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“…25 Furthermore, the use of a golden-angle radial acquisition combined with compressed sensing yielded acceleration factors up to 16. [25][26][27][28][29] In one recent approach, fetal data are acquired using a continuous golden angle radial trajectory. 26 Preliminary time-averaged reconstructions for each slice are used to confirm slice prescription and provide an initial assessment of gross fetal movement.…”

Section: Approaches To Triggered Cine Imaging Of the Fetal Heartmentioning

confidence: 99%

MR imaging of the fetal heart

Marini

Amerom

Saini

et al. 2019

Magnetic Resonance Imaging

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In the last decade, technological advances have enabled the acquisition of high spatial and temporal resolution cardiac magnetic resonance imaging (MRI) in the fetus. Fetal cardiac MRI has emerged as an alternative to ultrasound, which may be helpful to confirm a diagnosis of congenital heart disease when ultrasound assessment is hampered, for example in late gestation or in the setting of oligohydramnios. MRI also provides unique physiologic information, including vessel blood flow, oxygen saturation and hematocrit, which may be helpful to investigate cardiac and placental diseases. In this review, we summarize some of the main techniques and significant advances in the field to date. Level of Evidence: 5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2020;51:1030–1044.

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Self-gated fetal cardiac MRI with tiny golden angle iGRASP: A feasibility study

Abstract: 2 Technical Efficacy: Stage 1 J. MAGN. RESON. IMAGING 2017;46:207-217.

Cited by 55 publications

References 35 publications

Feasibility of real‐time cardiac MRI in mice using tiny golden angle radial sparse

Feasibility of real‐time cardiac MRI in mice using tiny golden angle radial sparse

Fetal iGRASP cine CMR assisting in prenatal diagnosis of complicated cardiac malformation with impact on delivery planning

MR imaging of the fetal heart

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