Self-Healable and Super-Tough Double-Network Hydrogel Fibers from Dynamic Acylhydrazone Bonding and Supramolecular Interactions

Hua, Jiachuan; Liu, Chang; Fei, Bin; Liu, Zunfeng

doi:10.3390/gels8020101

Cited by 12 publications

(8 citation statements)

References 58 publications

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“…3f-h). The toughness of the S-PAZr was higher than that of most current hydrogel fibers and well those of anhydrous polymers such as polydimethylsiloxane (PDMS), Kevlar, and synthetic rubber, even exceeding the toughness of natural tendon and spider silk 11,18,25,36,[53][54][55][56][57][58] .…”

Section: Broadly Adjustable Mechanical Properties Of the S-pazr Hydro...mentioning

confidence: 82%

Spider-silk-inspired strong and tough hydrogel fibers with anti-freezing and water retention properties

Wu,

Liu,

Gong

et al. 2024

Nat Commun

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Ideal hydrogel fibers with high toughness and environmental tolerance are indispensable for their long-term application in flexible electronics as actuating and sensing elements. However, current hydrogel fibers exhibit poor mechanical properties and environmental instability due to their intrinsically weak molecular (chain) interactions. Inspired by the multilevel adjustment of spider silk network structure by ions, bionic hydrogel fibers with elaborated ionic crosslinking and crystalline domains are constructed. Bionic hydrogel fibers show a toughness of 162.25 ± 21.99 megajoules per cubic meter, comparable to that of spider silks. The demonstrated bionic structural engineering strategy can be generalized to other polymers and inorganic salts for fabricating hydrogel fibers with broadly tunable mechanical properties. In addition, the introduction of inorganic salt/glycerol/water ternary solvent during constructing bionic structures endows hydrogel fibers with anti-freezing, water retention, and self-regeneration properties. This work provides ideas to fabricate hydrogel fibers with high mechanical properties and stability for flexible electronics.

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Section: Broadly Adjustable Mechanical Properties Of the S-pazr Hydro...mentioning

confidence: 82%

Spider-silk-inspired strong and tough hydrogel fibers with anti-freezing and water retention properties

Wu,

Liu,

Gong

et al. 2024

Nat Commun

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“…When subjected to dynamic loads, the dual-network structure of the hydrogel can disperse stress and absorb energy, thereby enhancing the toughness and fatigue resistance of the material. Hydrogen and dynamic imine bonds are reversible cross-linking bonds that can increase the elastic modulus and durability of the gel, slow down crack growth, and extend the service life of the material …”

Section: Resultsmentioning

confidence: 99%

“…Hydrogen and dynamic imine bonds are reversible cross-linking bonds that can increase the elastic modulus and durability of the gel, slow down crack growth, and extend the service life of the material. 43 3.3. In Vitro Cytocompatibility and Hemocompatibility of PCO Hydrogels.…”

Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 99%

Dynamically Cross-Linked Double-Network Hydrogels with Matched Mechanical Properties and Ideal Biocompatibility for Artificial Blood Vessels

Jia,

Huang,

Meng

et al. 2024

ACS Appl. Mater. Interfaces

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Vessel transplantation is currently considered the "gold standard" treatment for cardiovascular disease. However, ideal artificial vascular grafts should possess good biocompatibility and mechanical strength that match those of native autologous vascular tissue to promote in vivo tissue regeneration. In this study, a series of dynamic cross-linking double-network hydrogels and the resultant hydrogel tubes were prepared. The hydrogels (named PCO), composed of rigid poly(vinyl alcohol) (PVA), flexible carboxymethyl chitosan (CMCS), and a cross-linker of aldehydebased β-cyclodextrin (OCD), were formed in a double-network structure with multiple dynamical cross-linking including dynamic imine bonds, hydrogen bonds, and microcrystalline regions. The PCO hydrogels exhibited superior mechanical strength, good network stability, and fatigue resistance. Additionally, it demonstrated excellent cell and blood compatibility. The results showed that the introduction of CMCS/OCD led to a significant increase in the proliferation rate of endothelial cells seeded on the surface of the hydrogel. The hemolysis rate in the test was lower than 0.3%, and both protein adsorption and platelet adhesion were reduced, indicating an excellent anticoagulant function. The plasma recalcification time test results showed that endogenous coagulation was alleviated to some extent. When formed into blood vessels and incubated with blood, no thrombus formation was observed, and there was minimal red blood cell aggregation. Therefore, this novel hydrogel tube, with excellent mechanical properties, exhibits antiadhesive characteristics toward blood cells and proteins, as well as antithrombotic properties, making it hold tremendous potential for applications in the biomedical and engineering fields.

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“…According to the different types of molecular bonds, intrinsic self-healing systems are divided into selfhealing covalent bonds and self-healing non-covalent bonds. Of these, self-healing covalent bonds can be divided into disulfide bonds [62], acylhydrazone bonds [63], Diels-Alder thermally reversible reaction [64], etc. Self-healing non-covalent bonds can be classified as hydrogen bonds [65], ionic bonds [66], metal-ligand bonds [67], π-π stacking [68], etc.…”

Section: Intrinsic Self-healingmentioning

confidence: 99%

Recent Advances of Self-Healing Materials for Civil Engineering: Models and Simulations

Liao,

Zhang,

et al. 2024

Buildings

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Empowering materials with self-healing capabilities is an attractive approach for sustainable development. This strategy involves using different methods to automatically heal microcracks and damages that occur during the service life of materials or structures. Initially, this study begins with an in-depth exploration of self-healing characteristics found in materials such as concrete, asphalt, and polymers. The differences and comparative merits and demerits between autogenous (intrinsic) healing and autonomic (extrinsic) healing are discussed, and it is found that intrinsic healing is more promising. Subsequently, the study explores how models are applied to assess self-healing efficiency. The results indicate that time and temperature have significant impacts on the self-healing process. However, there is a scarcity of research exploring the effects of load factors during service life. Computational simulation methodologies for microcapsules and asphalt within self-healing materials are investigated. Multiscale characterization and machine learning can further elucidate the healing mechanisms and facilitate the establishment of computational models. This study endeavors to realize the maximum capabilities of self-healing materials, paving the way for the design of sustainable and more effective self-repairing materials for various applications.

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Self-Healable and Super-Tough Double-Network Hydrogel Fibers from Dynamic Acylhydrazone Bonding and Supramolecular Interactions

Cited by 12 publications

References 58 publications

Spider-silk-inspired strong and tough hydrogel fibers with anti-freezing and water retention properties

Spider-silk-inspired strong and tough hydrogel fibers with anti-freezing and water retention properties

Dynamically Cross-Linked Double-Network Hydrogels with Matched Mechanical Properties and Ideal Biocompatibility for Artificial Blood Vessels

Recent Advances of Self-Healing Materials for Civil Engineering: Models and Simulations

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