Self‐Healing Generalized Infantile Myofibromatosis with Elevated Urinary bFGF

Léauté‐Labrèze, Christine; Labarthe, M P; Blanc, J.-F.; Sanyas, P.; Dosquet, Christine; Taı̈eb, Alain

doi:10.1046/j.1525-1470.2001.01933.x

Cited by 23 publications

(17 citation statements)

References 13 publications

(33 reference statements)

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“…A few reports have documented a familial pattern with an autosomal dominant pattern and variable penetrance [151][152][153][154]. During the active growth phase, urinary beta-fibroblast growth factor levels may be elevated, suggesting a role for angiogenic stimulation [155].…”

Section: Infantile Myofibromatosismentioning

confidence: 99%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

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Fibroblastic and myofibroblastic tumors in children and adolescents are a relatively common group of soft tissue proliferations that range from reactive to hamartomatous to neoplastic, with a full spectrum of benign, intermediate, and malignant neoplasms. These lesions are diagnostically challenging because of morphologic and immunohistochemical overlap, despite significant clinical, genetic, and prognostic differences. The fibromatoses are a major subgroup, and all types of fibromatoses can occur in the 1st 2 decades of life. Intermediate and malignant fibroblastic-myofibroblastic tumors are an important group that includes variants of fibrosarcoma and other tumors with recurrent cytogenetic or molecular genetic abnormalities and low metastatic potential. Pathologic examination is enhanced by adjunct techniques, such as immunohistochemistry, cytogenetics, and molecular genetics, although morphology provides the ultimate criteria for a specific diagnosis. This article reviews the clinicopathologic features of fibroblastic and myofibroblastic tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents, the use of diagnostic adjuncts, and differential diagnoses.

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Section: Infantile Myofibromatosismentioning

confidence: 99%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

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“…Histopathology clearly distinguishes myofibroma from IH, typically revealing a biphasic pattern of peripheral smooth muscle-like fascicles of spindle cells and central areas resembling haemangiopericytoma with rounded pericytes. 9,10 Smooth muscle stains are positive. IM tends to spontaneous disappearance and intervention is usually reserved for symptomatic lesions or when internal organ function is compromised.…”

Section: Infantile Myofibromatosis and Haemangiopericytomamentioning

confidence: 99%

“…e. Pilomatricomas show features of calcification on ultrasound evaluation. 10. Concerning infantile myofibromatosis and haemangiopericytoma:…”

Section: Professional Development Programmentioning

confidence: 99%

Conditions masquerading as infantile haemangioma: Part 2

2009

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“…Infantile myofibromatosis may arise in a solitary or multicentric form, with similar histopathologic findings but different clinical features and prognosis. The diagnostic and evolving criteria of this disease are well known to date [4], but the etiology of this disorder remains unclear [5,6]. Complete surgical excision is the procedure of choice in solitary myofibromatosis with 10% recurrence rate [4][5][6][7] and is sometimes required for obstructive or locally destructive tumors.…”

Section: Discussionmentioning

confidence: 99%