Self-Healing Juvenile Cutaneous Mucinosis

Aydıngöz, İkbal Esen; Candan, İsfendiyar; Dervent, Barış

doi:10.1159/000018180

Cited by 21 publications

(14 citation statements)

References 3 publications

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“…Table I summarizes the findings of our cases as well as those of other reported cases of SHJCM, and Table II shows the main clinical and histologic features of other diseases that are included in the differential diagnosis of SHJCM. [26][27][28][29] As is evident from our case histories, we experienced difficulty in making the correct diagnosis. Our aim is to assist other clinicians and pathologists in similar cases, especially when potentially misleading histologic features are present in a relatively rare condition.…”

Section: Discussionmentioning

confidence: 99%

Self-healing juvenile cutaneous mucinosis: Cases highlighting subcutaneous/fascial involvement

Nagaraj¹,

Fangman²,

White³

et al. 2006

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Self-healing juvenile cutaneous mucinosis: Cases highlighting subcutaneous/fascial involvement

Nagaraj¹,

Fangman²,

White³

et al. 2006

Journal of the American Academy of Dermatology

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“…in 1973 as self‐healing juvenile cutaneous mucinosis (SHJCM) 2 . SHJCM has been described in a total of 10 cases in published work 2–11 . In these reports of juvenile variants, the patients’ ages ranged from 1–15 years and included eight boys and two girls.…”

Section: Discussionmentioning

confidence: 99%

“…In these reports of juvenile variants, the patients’ ages ranged from 1–15 years and included eight boys and two girls. The duration of the lesions ranged from a few weeks to 2 years 2–11 . The patients often had systemic symptoms, such as fever, arthralgias and weakness, 3,11 but usually did not have an internal association.…”

Section: Discussionmentioning

confidence: 99%

Adult variant of self‐healing papular mucinosis in a patient with rheumatoid arthritis: Predominant proliferation of dermal dendritic cells expressing CD34 or factor XIIIa in association with dermal deposition of mucin

Yokoyama¹,

Murakami²

2006

The Journal of Dermatology

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According to a recent classification, self-healing papular mucinosis (SHPM) is a subtype of papular mucinosis (also known as lichen myxedematosus), which is in turn a type of idiopathic localized cutaneous mucinosis. SHPM tends to occur in children, but there have been a few reports of an adult type. We report a 70-year-old Japanese woman who presented with reddish, rice-kernel-sized papules of a few days' duration on her right arm. She had a 25-year history of rheumatoid arthritis, which had been well treated with a low dose of corticosteroid as well as some other medications. No paraproteinemia or thyroid dysfunction were observed. The eruptions spontaneously resolved within 2.5 months of onset. Histological findings showed a well-circumscribed mucinous stroma surrounded by dermal mesenchymal cells, such as fibroblast-like cells in the middle of the dermis. Immunohistochemically, these cells were positive only for vimentin on the mucinous lesion. On the circumference of the mucinous lesion, these cells expressed either CD34 or factor XIIIa (FXIIIa). Because vimentin was common to dermal mesenchymal cells, we defined the cells expressing CD34 or FXIIIa, except for vimentin+ cells lacking CD34 or FXIIIa, as dermal dendritic cells (DDC). The findings of the present case suggest that CD34+ or FXIIIa+ DDC and tryptase-positive mast cells on the perilesional area in combination with vimentin+ cells on the mucinous lesion might have given rise to the dermal deposition of mucin in our case. These cells, which are possibly activated in an autoimmune manner associated with rheumatoid arthritis, might play important roles in the development of dermal deposition of mucin in SHPM.

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“…The localized variants comprise five subtypes including discrete papular LM, acral persistent papular mucinosis, juvenile and adult variant of self-healing papular mucinosis, papular mucinosis of the infancy and nodular LM [3, 4, 2, 5]. As the morphology of the case reported herein does not fit well into the localized variants as described, we would assign our observation to the third group of the atypical forms of mucinoses.…”

Section: Discussionmentioning

confidence: 71%

Plaque-Like Sclerodermiform Localized Mucinosis Rapidly Responsive to Topical Tacrolimus

Schmaltz

Vogt²,

Müller³

2010

Case Rep Dermatol

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We report the successful treatment of plaque-like sclerodermiform mucinosis using tacrolimus ointment topically. We present a 70-year-old male with a large chronic erythema and hardening of the nuchal skin and shoulder area. Subjective symptoms were a moderate pruritus and a rather disabling stiffness. A biopsy specimen revealed typical features of lichen myxedematosus. In a subsequent clinical examination, no associated illnesses such as hypothyroidism or gammopathy were found. Since no established therapy exists for this condition, and as there was a lack of response to potent topical glucocorticosteroids, tacrolimus 0.03% ointment was used off-label twice daily. Surprisingly, this resulted in a rapid, almost complete clearance of the skin within three weeks of treatment.

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Self-Healing Juvenile Cutaneous Mucinosis

Cited by 21 publications

References 3 publications

Self-healing juvenile cutaneous mucinosis: Cases highlighting subcutaneous/fascial involvement

Self-healing juvenile cutaneous mucinosis: Cases highlighting subcutaneous/fascial involvement

Adult variant of self‐healing papular mucinosis in a patient with rheumatoid arthritis: Predominant proliferation of dermal dendritic cells expressing CD34 or factor XIIIa in association with dermal deposition of mucin

Plaque-Like Sclerodermiform Localized Mucinosis Rapidly Responsive to Topical Tacrolimus

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