Self‐Healing Microencapsulation of Biomacromolecules without Organic Solvents

Reinhold, Samuel E.; Desai, Kashappa‐goud H.; Zhang, Li; Olsen, Karl; Schwendeman, Steven P.

doi:10.1002/ange.201206387

Cited by 12 publications

(23 citation statements)

References 22 publications

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“…S1H). As "self-healing" is a unique phenomenon of PLA that occurs at temperatures close to PLA's glass transition temperature (36,37) (T g = 41.42°C; fig. S1E), spontaneous rearrangement of the polymer chains was triggered by gentle infrared (IR) irradiation ( fig.…”

Section: Self-healing Microcapsules Facilitated Antigen Loadingmentioning

confidence: 99%

Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

Wang

et al. 2020

Sci. Adv.

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Therapeutic cancer vaccines that harness the immune system to reject cancer cells have shown great promise for cancer treatment. Although a wave of efforts have spurred to improve the therapeutic effect, unfavorable immunization microenvironment along with a complicated preparation process and frequent vaccinations substantially compromise the performance. Here, we report a novel microcapsule-based formulation for high-performance cancer vaccinations. The special self-healing feature provides a mild and efficient paradigm for antigen microencapsulation. After vaccination, these microcapsules create a favorable immunization microenvironment in situ, wherein antigen release kinetics, recruited cell behavior, and acid surrounding work in a synergetic manner. In this case, we can effectively increase the antigen utilization, improve the antigen presentation, and activate antigen presenting cells. As a result, effective T cell response, potent tumor inhibition, antimetastatic effects, and prevention of postsurgical recurrence are achieved with various types of antigens, while neoantigen was encapsuled and evaluated in different tumor models.

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Section: Self-healing Microcapsules Facilitated Antigen Loadingmentioning

confidence: 99%

Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

Wang

et al. 2020

Sci. Adv.

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“…Following a single injection, the implants/depots can provide intratumoral therapeutic levels of anti-cancer agents for an extended period of time (a few months). 49,[62][63][64] Because these systems are composed of biodegradable and biocompatible polymers, such as poly(D,L lactic-co-glycolic acid) (PLGA) and poly(D,L lactide) (PLA), 63,64,[183][184][185][186] there is no need for a second surgery to remove the systems or to avoid a chronic foreign-body immune response. 73 The implantable systems also alleviate multiple dosing schedules and the poor patient compliance concerns that are associated with the traditional local delivery vehicles described above.…”

Section: Injectable Systems Based On Biodegradable Polymersmentioning

confidence: 99%

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Desai

2017

J Biomed Mater Res

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Oral cancer is among the most prevalent cancers in the world. Moreover, it is one of the major health problems and causes of death in many regions of the world. The traditional treatment modalities include surgical removal, radiation therapy, systemic chemotherapy, or a combination of these methods. In recent decades, there has been significant interest in intraoral site-specific chemoprevention via local drug delivery using polymeric systems. Because of its easy accessibility and clear visibility, the oral mucosa is amenable for local drug delivery. A variety of polymeric systems-such as gels, tablets, films, patches, injectable systems (e.g., millicylindrical implants, microparticles, and in situ-forming depots), and nanosized carriers (e.g., polymeric nanoparticles, nanofibers, polymer-drug conjugates, polymeric micelles, nanoliposomes, nanoemulsions, and polymersomes)-have been developed and evaluated for the local delivery of natural and synthetic chemopreventive agents. The findings of in vitro, ex vivo, and in vivo studies and the positive outcome of clinical trials demonstrate that intraoral site-specific drug delivery is an attractive, highly effective and patient-friendly strategy for the management of oral cancer. Intraoral site-specific drug delivery provides unique therapeutic advantages when compared to systemic chemotherapy. Moreover, intraoral drug delivery systems are self-administrable and can be removed when needed, increasing patient compliance. This article covers important aspects and advances related to the design, development, and efficacy of polymeric systems for intraoral site-specific drug delivery. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1383-1413, 2018.

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“…On one hand, physical adsorption of VEGF onto the surface would lead to uncontrolled burst release and very limited effects on ECs. On the other, direct encapsulation of VEGF within the drug coating would inevitably require contact with organic solvents, which significantly impairs the bioactivity of VEGF [31]. Moreover, current studies on coating methods have barely provided any insight into the harsh sterilization process of industrial production of DES, which further rises a challenge to VEGF bioactivity [32,33].…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Capillary Coating to Biofunctionlize Drug-Eluting Stent for Improving Endothelium Regeneration

et al. 2020

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The drug-eluting stent (DES) has become one of the most successful and important medical devices for coronary heart disease, but yet suffers from insufficient endothelial cell (EC) growth and intima repair, eventually leading to treatment failure. Although biomacromolecules such as vascular endothelial growth factor (VEGF) would be promising to promote the intima regeneration, combining hydrophilic and vulnerable biomacromolecules with hydrophobic drugs as well as preserving the bioactivity after harsh treatments pose a huge challenge. Here, we report on a design of hierarchical capillary coating, which composes a base solid region and a top microporous region for incorporating rapamycin and VEGF, respectively. The top spongy region can guarantee the efficient, safe, and controllable loading of VEGF up to 1 μg/cm2 in 1 minute, providing a distinctive real-time loading capacity for saving the bioactivity. Based on this, we demonstrate that our rapamycin-VEGF hierarchical coating impressively promoted the competitive growth of endothelial cells over smooth muscle cells (ratio of EC/SMC~25) while relieving the adverse impact of rapamycin to ECs. We further conducted the real-time loading of VEGF on stents and demonstrate that the hierarchical combination of rapamycin and VEGF showed remarkable endothelium regeneration while maintaining a very low level of in-stent restenosis. This work paves an avenue for the combination of both hydrophobic and hydrophilic functional molecules, which should benefit the next generation of DES and may extend applications to diversified combination medical devices.

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Self‐Healing Microencapsulation of Biomacromolecules without Organic Solvents

Cited by 12 publications

References 22 publications

Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination

Polymeric drug delivery systems for intraoral site‐specific chemoprevention of oral cancer

Hierarchical Capillary Coating to Biofunctionlize Drug-Eluting Stent for Improving Endothelium Regeneration

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