Self-healing supramolecular heterometallic gels based on the synergistic effect of the constituent metal ions

Yan, Liwei; Shen, Linghong; Lv, Mingqian; Yu, Wenkun; Chen, Jie; Wang, Shuang; Fu, Xiaofang; Ye, Zhongbin

doi:10.1039/c5cc08421k

Cited by 21 publications

(14 citation statements)

References 27 publications

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“…24 The preparation of bulk self-healable gels through noncovalent interactions without the use of "polymers'' remains challenging due to their intrinsic viscoelasticity. 27 15 are not included here. Detailed studies on the underlying self-healing mechanisms of different gels have been previously reviewed.…”

Section: Self-healing Gelsmentioning

confidence: 99%

Self-Healable Gels for Use in Wearable Devices

et al. 2017

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Self-healing gels, which are able to restore their original shape/condition after damage, have recently attracted considerable interest. The present review provides an update on the current status of self-healing gels for use in soft self-healing devices, with the main focus on wearable devices. Following a brief introduction of conventional self-healing gels, this review summarizes the current strategies for synthesizing self-healing gels, comparing the properties of polymeric and small molecular selfhealing gels. Some of the strengths and weaknesses of these two types of self-healing gels are clearly highlighted. Several typical instances to outline the emerging applications of self-healing gels with partially or fully self-healing devices/materials, including wearable sensors, supercapacitors, lithium batteries, and coatings, are provided. Finally, the current challenges and future perspectives regarding the further development of self-healing gels are also discussed.

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Section: Self-healing Gelsmentioning

confidence: 99%

Self-Healable Gels for Use in Wearable Devices

et al. 2017

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“…23a). 105 When a DMF solution of L15 was mixed with a DMF solution of NiCl 2 Á6H 2 O or CoCl 2 Á6H 2 O at room temperature, the mixture spontaneously formed monometallic CPGs, L15-Ni and L15-Co, respectively. They explained that the cooperative hydrogen bonding interaction of the NH group of L15 played an important role in gelation.…”

Section: Self-healing In Cpgsmentioning

confidence: 99%

Coordination polymer gels: soft metal–organic supramolecular materials and versatile applications

2016

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In recent times, significant attention has been paid to the development of functional coordination polymer gels (CPGs) from rationally designed low molecular weight gelators (LMWGs) and metal ions. Coordination of metal ions to LMWGs provides an opportunity to emulate metal based redox, optical, electronic and magnetic properties in soft CPG materials. The metal-LMWG interactions allow controlled growth of CPGs with different nanostructures such as fibers, tubes, rings, ribbons and vesicles. Furthermore, the nanoscale periodicity of metal ions and LWMGs in CPGs is of paramount importance for different optoelectronic applications. The easy processability and dynamic nature of CPGs are explored for application in diverse fields, including drug-delivery, gas storage, optoelectronics, chemo-sensing, self-healing, etc. Also, by taking advantage of dynamic metal-ligand coordination bonds various stimuli-responsive multi-functional CPGs are developed. In this feature article, we cover important examples of newly developed CPGs, which show potential applications in different fields.

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“…35,36 Yan et al reported a self-healing supramolecular heterometallic MOG based on Co 2+ and Ni 2+ ions exhibiting the synergistic effect of the constituent metal ions. 37 Di ́az et al fabricated a Cu 2+ -based self-healing MOG, which showed proton conducting properties. 38 Yu and coworkers reported a self-healing hybrid gel based on Zn-tpy and polypyrrole, which showed conductivity.…”

Section: Introductionmentioning

confidence: 99%

“…The self-healing properties of MOGs are governed by various interactions, such as reversible coulombic interactions, molecular recognitions, hydrogen bonding, hydrophobic interactions, and metal–ligand coordination. Quite a few reports of MOGs exhibiting self-healing property have been reported in literature. , Yan et al reported a self-healing supramolecular heterometallic MOG based on Co 2+ and Ni 2+ ions exhibiting the synergistic effect of the constituent metal ions . Díaz et al fabricated a Cu 2+ -based self-healing MOG, which showed proton conducting properties .…”

Section: Introductionmentioning

confidence: 99%

A Self-Healing Metal–Organic Gel (MOG) Exhibiting pH-Responsive Release of a Chemotherapeutic Agent, Doxorubicin: Modulation of Release Kinetics by Partial Dehydration of Matrix

Sharma

Singh

et al. 2019

ACS Omega

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Use of soft and porous metal−organic gels (MOGs), formed by metal−ligand coordination, has generated immense research interest in fields like conductance, catalysis, chemical sensing, and dye adsorption, but there are only few reports on their use in drug delivery, particularly cancer drug delivery. Consequently, a Cr 3+ -based metal− organic gel (MOG1) was synthesized from Cr(NO 3 ) 3 •9H 2 O and 2,2′bipyridine-4,4′-dicarboxylic acid (BPDA) in DMF, using a solvothermal route. The gel exhibited strong resilience when subjected to a dynamic frequency sweep from 1−100 rad/sec at a constant strain of 0.1% and minimal loss of storage modulus when subjected to repeated cycles of 0.1 and 100% strain for 60 s, and it exhibited self-healing characteristics. The doxorubicin (DOX)-loaded gels were developed to assess the drug release profiles at physiological (7.4) and intratumoral (6.4) pH and found to be pH-dependent. A sustained zero-order release of 54% drug was obtained after 48 h at pH 7.4 and, a faster release, with 87.4% of the drug being released in 12 h following pseudo-Fickian diffusion at pH 6.4. The most unique feature of the gel, not reported earlier, was the transformation of the drug release kinetics from zero order to exponential decay upon dehydration to 80% of its original weight. The drug release slowed down further when the gel was dehydrated to 50% of its original weight. The cell viability assay showed no significant toxicity of MOG1 to mdck (kidney epithelial) cell lines, and more than 75% cells were viable, even after 72 h, with concentrations up to 100 μg/mL, whereas the DOX-loaded MOG1 demonstrated dose-dependent toxicity to cancer cell lines (A549) in the concentration range investigated (0.1−5 μg/mL equivalent DOX). Fluorescence microscopy studies revealed efficient internalization of DOX released from MOG1 into cancer cells. The gel may be employed as an injectable depot for quick and selective delivery of a chemotherapeutic agent to tumoral sites.

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Self-healing supramolecular heterometallic gels based on the synergistic effect of the constituent metal ions

Abstract: Supramolecular heterometallic gels with synergistic properties were prepared for the first time using ligand with Co(2+) and Ni(2+), and their macroscopic self-healing has been achieved by improving the unfavorable viscoelasticity of each monometallic gel.

Cited by 21 publications

References 27 publications

Self-Healable Gels for Use in Wearable Devices

Self-Healable Gels for Use in Wearable Devices

Coordination polymer gels: soft metal–organic supramolecular materials and versatile applications

A Self-Healing Metal–Organic Gel (MOG) Exhibiting pH-Responsive Release of a Chemotherapeutic Agent, Doxorubicin: Modulation of Release Kinetics by Partial Dehydration of Matrix

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