Insertion of peripheral intravenous (I.V.)lines is a key component for almost every patient who arrives to casualty for seeking treatment. In adults, routinely 18G or 20G plastic cannula are used. Although placement of these invasive devices is seen as a benign part of the daily practice particularly by junior staff, many complications like infiltration, thrombophlebitis, venous spasm, hematoma, air embolism, cannula associated blood stream infection and nerve, tendon and ligament injury can occur. Fracture of I.V. canula inside the vein is rare. We present a case series of 2 patients who presented with such complications. A brief case series & review of literature is presented.