Self-inflicted Testicular Amputation in First Lysergic Acid Diethylamide Use

Blacha, Christian; Schmid, Markus; Gahr, Maximilian; Freudenmann, Roland W.; Plener, Paul L.; Finter, F.; Connemann, Bernhard J.; Schönfeldt‐Lecuona, Carlos

doi:10.1097/adm.0b013e318279737b

Cited by 10 publications

(2 citation statements)

References 10 publications

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“…In these cases, the contribution of mental illness to the self-aggressive act is substantial, and one cannot attribute the act exclusively to LSD exposure. Only the case reported by Blacha et al [ 21 ] appears to be of real interest, in that it concerns manual amputation of both testes after first use of LSD in combination with alcohol consumption in a 32-year-old man with no psychiatric history and whose follow-up examination 6 months after the event did not reveal the development of a psychiatric disorder.…”

Section: Discussionmentioning

confidence: 99%

Self-inflicted neck wounds under influence of lysergic acid diethylamide

Daré¹,

Gicquel²,

Baert

et al. 2020

Medicine

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Rationale: Lysergic acid diethylamide (LSD) is a highly potent psychedelic drug derived from ergot alkaloids. The available literature data derived from controlled studies or usage in a medical setting seem reassuring; however the literature contains very rare cases of fatal self-inflicted injuries associated with LSD exposure. The behavioral disorder that created the conditions conducive to death is a maladaptive or irrational response to the psychiatric manifestations induced by the substance. Patient concern: Here, we report the case of a 26-year-old man found dead with large neck wounds in a locked house. No medical history other than recreational use of alcohol and narcotics was reported as well as any history of psychotic disease. The entirety of the other investigations carried out did not demonstrate the presence of a third party at the place of death and a dropper bottle containing LSD was found near the body. Diagnosis: We report the first case of fatal self-inflicted neck wounds with a cutting instrument in the context of acute exposure to LSD in a patient with no psychiatric history and without suicidal symptoms at the time of the self-aggressive act. Intervention and outcomes: In the present work, we used a validated method using liquid chromatography coupled with mass spectrometry for simultaneous quantification of LSD and its metabolites (O-H-LSD and Nor-LSD) in whole blood and urine samples. LSD and O-H-LSD were respectively found at 1460 and 182 pg/mL in blood. In the urine, the concentrations of LSD, nor-LSD, O-H-LSD were, respectively, 3670, 201, and 4890 ng/L. Lessons: This observation is particularly relevant in view of the resurgence of interest in the therapeutic use of LSD, notwithstanding the fact that the literature has not demonstrated a link between suicidal risk and acute or chronic exposure to LSD.

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Section: Discussionmentioning

confidence: 99%

Self-inflicted neck wounds under influence of lysergic acid diethylamide

Daré¹,

Gicquel²,

Baert

et al. 2020

Medicine

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“…For example, lifetime use of other illicit substances such as marihuana was associated with past-year suicidal thinking and past-month psychological distress, and 97.7% and 97.8%, respectively, of the psychedelic users also reported lifetime marihuana use [88,89]. Furthermore, several case reports describe harmful behavior in particular when psychedelics were consumed together with other psychotropic substances, e.g., alcohol [90][91][92]. An online survey about the single most challenging experience with recreational psilocybin use revealed that 11% put themselves or others at risk of harm, 7.6% sought treatment because of enduring psychological problems, and three cases were associated with the onset of enduring psychotic symptoms [93].…”

Section: Physical and Mental Harm Potentialmentioning

confidence: 99%

Rediscovering Psilocybin as an Antidepressive Treatment Strategy

2021

Self Cite

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There has recently been a renewal of interest in psychedelic research on the use of psilocybin in psychiatric treatment and, in particular, for the treatment of major depressive disorder (MDD). Several state-of-the-art studies have provided new insight into the mechanisms of action of psilocybin and its therapeutic potential. Nevertheless, many questions remain unanswered. With this review, we provide an overview of the current state of research on the potential mechanisms of psilocybin, its antidepressant potential, and the associated risks and adverse effects, to provide an update on a controversial topic discussed in psychopharmacology. A database search was conducted in Medline including articles on psilocybin over the period of the last 20 years. Despite the promising progress in understanding the mechanisms of psilocybin, the exact antidepressive mechanism and the role of the psychedelic experience remain elusive. The studies included in this review found high treatment effect sizes for psilocybin as an antidepressant. However, the results must be regarded as preliminary due to several limitations. Although the current studies observed no severe adverse events, several questions regarding safety and utility remain and must be subject of future research.

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Schäden des Zentralnervensystems bei Drogenkonsum

Bachhuber

2018

Radiologe

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Self-inflicted Testicular Amputation in First Lysergic Acid Diethylamide Use

Abstract: This report shows that a first and single use of lysergic acid diethylamide in combination with alcohol can cause intoxication with dramatic consequences.

Cited by 10 publications

References 10 publications

Self-inflicted neck wounds under influence of lysergic acid diethylamide

Self-inflicted neck wounds under influence of lysergic acid diethylamide

Rediscovering Psilocybin as an Antidepressive Treatment Strategy

Schäden des Zentralnervensystems bei Drogenkonsum

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