Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms

Symons, Frank J.

doi:10.1016/j.neubiorev.2011.01.002

Cited by 50 publications

(44 citation statements)

References 87 publications

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“…While head banging is a behavior often associated with developmental disorders (Symons, 2011), there are not high rates of developmental disorders in the current study’s sample. We are unclear about possible reasons for this method of self-injury being more prevalent in the current study than in previous research.…”

Section: Discussionmentioning

confidence: 67%

Non-suicidal self-injury and suicide attempts in a New Zealand birth cohort

Coppersmith

Nada-Raja

Beautrais

2017

Journal of Affective Disorders

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Background Non-suicidal self-injury (NSSI) and suicide attempts are related, but distinct behaviors. The primary aim of the current study was to identify factors that distinguish those with different lifetime histories of self-injury. A secondary aim was to test whether lifetime history of self-injury at age 26 predicted current suicide ideation at age 32. Methods Participants were 26 year olds from a large birth cohort with a lifetime history of no self-injury (n = 466), a lifetime history of NSSI (n = 191), or a lifetime history of NSSI and a suicide attempt (NSSI+SA; n = 52). They were compared on a history of psychiatric disorders, 12-month suicide ideation, lifetime history of childhood sexual abuse, and lifetime exposure to suicide. Results An anxiety disorder, a substance dependence disorder, suicide ideation, and a history of childhood sexual abuse distinguished the NSSI+SA and NSSI only groups. Longitudinal results demonstrated that a history of NSSI predicted future suicide ideation after adjusting for other selected risk factors. Limitations The majority of analyses are cross-sectional which limits inferences about causality. The retrospective self-report for lifetime behavior could be subject to reporting biases. Conclusions Adults with a history of NSSI and adults with a history of NSSI and a suicide attempt are clinically distinct groups that are both at risk of future suicide ideation. Identifying and treating NSSI could be a key preventive factor in reducing subsequent suicide risk.

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Section: Discussionmentioning

confidence: 67%

Non-suicidal self-injury and suicide attempts in a New Zealand birth cohort

Coppersmith

Nada-Raja

Beautrais

2017

Journal of Affective Disorders

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“…This underscores the importance of ensuring routine preventive dental care for all children with IDDs (Authors, 2012b). Second, children with IDDs may have impaired peripheral nociceptors (Symons, 2011) or difficulties communicating dental pain (Breau & Burkitt, 2009), which could lead to reduced NTDC-related ED admissions even though underlying symptoms are present. Future research should examine the extent to which underreporting of dental pain that could lead to reduced ED admissions is a problem for children with IDDs.…”

Section: Discussionmentioning

confidence: 99%

U.S. Emergency Department Admissions for Nontraumatic Dental Conditions for Individuals With Intellectual and Developmental Disabilities

Donald¹,

Masterson²,

Wong³

2014

Intellectual and Developmental Disabilities

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We hypothesized that individuals with intellectual and developmental disabilities (IDDs) are more likely to have an emergency department (ED) admission for non-traumatic dental conditions (NTDCs). We analyzed 2009 U.S. National Emergency Department Sample data and ran logistic regression models for children ages 3-17 years and adults ages 18+ years. The prevalence of NTDC-related ED admissions was 0.8% for children and 2.0% for adults. Children with IDDs were at increased odds of NTDC-related ED admission, but this difference was not statistically significant (pOR=1.06; 95% CI=0.91,1.23). Adults with IDDs had significantly lower odds of an ED admission for NTDCs (pOR=0.49;95% CI=0.44,0.54). Children with IDDs are not at increased odds of NTDC-related ED admissions whereas adults with IDDs are at significantly reduced odds.

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“…Disruptions in sensory processing have been shown to be the most important risk factor for NSSI in children and adolescents with autism spectrum disorders (Duerden et al, 2012). For instance, a model has been proposed in which the mechanisms regulating peripheral and central transmission of painful stimuli are related to and regulate self-injury in this population (Symons, 2011). In this nociceptive model, which involves pain sensitivity, the self-inflicted injury incites a cascade of peripheral sensory and neurochemical events.…”

Section: Cognitive Systemsmentioning

confidence: 99%

Conceptualizing the neurobiology of non-suicidal self-injury from the perspective of the Research Domain Criteria Project

Schreiner

Klimes‐Dougan

Begnel

et al. 2015

Neuroscience & Biobehavioral Reviews

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Non-suicidal self-injury (NSSI) commonly starts in adolescence and is associated with an array of negative outcomes. Neurobiological research investigating NSSI is in its early stages and most studies have examined this behavior within the context of specific diagnoses. However, the Research Domain Criteria (RDoC) initiative encourages researchers to examine brain-behavior relationships across diagnoses. This review on the neurobiology associated with NSSI is organized using the domains proposed by RDoC: Negative Valence, Positive Valence, Cognitive, Social Processes, and Arousal/Regulatory Systems. Evidence of neurobiological anomalies is found in each of these domains. We also propose future research directions, especially in regard to human development. Future NSSI studies should address this behavior independent of diagnosis, examine relevant constructs across multiple units of analysis, and assess how systems change across development and course of illness. These advances will be essential for guiding neurobiologically informed intervention and prevention strategies to target NSSI. In doing so, we may prevent the associated negative outcomes across the lifespan.

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Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms

Cited by 50 publications

References 87 publications

Non-suicidal self-injury and suicide attempts in a New Zealand birth cohort

Non-suicidal self-injury and suicide attempts in a New Zealand birth cohort

U.S. Emergency Department Admissions for Nontraumatic Dental Conditions for Individuals With Intellectual and Developmental Disabilities

Conceptualizing the neurobiology of non-suicidal self-injury from the perspective of the Research Domain Criteria Project

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