Self-limited Colitis during the Course of Rubella and Cytomegalovirus Infection in an Immunocompetent Adult

Sugisaki, Kota; Maekawa, Satoshi; Mori, Kenji; Ichii, Osamu; Kanda, Kikuo; Tai, Mayumi; Suzuki, Tomohiro; Ochiai, Hironobu; Ejiri, Yutaka; Takahashi, Masashi; Hakozaki, Hando

doi:10.2169/internalmedicine.43.404

Cited by 7 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar IgM antibody fl uctuation was reported in a patient with cytomegalovirus reactivation. 5 We consider that the fi ndings of positive anti-VZV IgM antibody in the CSF and negativity in the serum support the idea of endogenous VZV reactivation, because exogenous VZV is considered to spread initially through the blood circulation, establishing viremia, and this is assumed to result in anti-VZV antibody production in the serum before the CSF. We also presume that the latent VZV was spread chiefl y by axonal transport rather than via the blood circulation, following the lower production of serum anti-VZV IgM antibody.…”

Section: Discussionmentioning

confidence: 81%

Varicella zoster virus meningoencephalitis accompanied by sporadic skin lesions in an older immunocompetent adult

Sugisaki¹,

Yoshida²

2007

Journal of Infection and Chemotherapy

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 81%

Varicella zoster virus meningoencephalitis accompanied by sporadic skin lesions in an older immunocompetent adult

Sugisaki¹,

Yoshida²

2007

Journal of Infection and Chemotherapy

Self Cite

View full text Add to dashboard Cite

“…Cases included in the analysis included patients with underlying UC (biopsyproven) and probable primary CMV documented by a positive CMV IgM and IgG serology [6,[9][10][11][12][13][14][15][16][17][18][19][20]. The results are presented in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Primary Infection with Cytomegalovirus in Ulcerative Colitis

2006

View full text Add to dashboard Cite

“…7,46 Almost 60% to 90% of adults are asymptomatic CMV carriers, and it is also possible that a focal, clinically occult reactivation of the virus could occur as an incidental finding in surveillance polypectomy specimens, but the absence of classic inclusions on routine hematoxylin stain and the uniformly negative results on immunohistochemical stain, a more sensitive and specific method for the detection of CMV, essentially excludes this diagnosis. In most of cases, CMV disease is due to reactivation of latent infection in the setting of an altered immune status; but on rare occasion, it can also occur in an apparently immunocompetent adult.…”

Section: Discussionmentioning

confidence: 99%

Multinucleated Epithelial Giant Cells in Colorectal Polyps

Kambham

Troxell

Longacre

2005

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Multinucleated epithelial giant cells (MEG) simulating viral cytopathic effect and/or dysplasia have been reported in the esophagus in association with inflammation, but the occurrence of similar cells in the colon has not been documented. Twenty-three colon specimens (22 biopsies and 1 partial colectomy) featuring MEG from 21 patients were evaluated for a variety of histologic features and correlated with clinical, endoscopic, and follow-up data. Patients included 9 males and 12 females (mean age, 64.9 years; range, 45-86 years). Eleven cases were obtained from 10 asymptomatic patients undergoing surveillance biopsies. Presenting symptoms in the remaining patients were dyspepsia, anemia, abdominal pain, and hematochezia. Over half (13 of 23) of the specimens were from descending and rectosigmoid colon, and almost all were visualized as polyps on endoscopy. Microscopically, all but 1 of the cases featured multiple MEG (range, 6 to >50 cells per biopsy) in the base and mid crypt zones of inflamed polyps with serrated architecture. Immunohistochemical stains for CMV, HSV, adenovirus, EBV, and polyoma virus were negative and no viral particles were identified on ultrastructural examination. Nuclear staining for hMLH1 and hMSH2, markers of microsatellite instability, was similar in distribution to adjacent serrated crypts, but reduced staining intensity was noted in occasional multinucleated cells. Expression of Ki-67 and cleaved caspase 3 was consistent with a quiescent or low proliferative state. Clinical follow-up was available for 9 patients (mean duration, 22.7 months). One patient died of heart failure; all others were well at last follow-up. Bizarre MEG may occasionally be seen within the crypts of inflamed polyps with serrated architecture, raising concern for dysplasia or viral infection. Immunohistochemical and ultrastructural studies fail to establish a viral etiology, and follow-up does not indicate clinically aggressive disease. These changes appear to represent a nonspecific, possibly degenerative response to inflammation and injury, and should be distinguished from dysplasia.

show abstract

Self-limited Colitis during the Course of Rubella and Cytomegalovirus Infection in an Immunocompetent Adult

Abstract: Abstract

Cited by 7 publications

References 24 publications

Varicella zoster virus meningoencephalitis accompanied by sporadic skin lesions in an older immunocompetent adult

Varicella zoster virus meningoencephalitis accompanied by sporadic skin lesions in an older immunocompetent adult

Primary Infection with Cytomegalovirus in Ulcerative Colitis

Multinucleated Epithelial Giant Cells in Colorectal Polyps

Contact Info

Product

Resources

About