Objective: To investigate the association between transaminase elevation
during the first trimester and early pregnancy loss (EPL) in patients
with recurrent spontaneous abortion (RSA). Further, the contributing
risk factors for transaminase elevation in early pregnancy in RSA
patients were analyzed Design: Cross-sectional study Setting: China
Population: RSA patients during the first trimester Methods: Patients
were divided into EPL group and N-EPL group as well as
transaminase-elevated group (TE group) and transaminase-normal group (TN
group). The relationship between transaminase level and EPL and the risk
factors of elevated transaminase were investigated via student’s t test,
Pearson chi-square test and logistic regression analyses. Main outcome
measure: The association between transaminase elevation and EPL and the
risk factors for elevated transaminase. Results: Higher serum
transaminase levels were observed in EPL group than in the N-EPL group
(p <0.05). Comparing with TN group, EPL is more common in TE
group (p =0.018). There is still a correlation between elevated
transaminases and EPL in RSA patients after adjusting for covariates
(AST: OR, 1.018; 95% CI, 1.007-1.029; p, 0.001; ALT: OR, 1.006; 95%CI,
1.001-1.011; p, 0.018). The higher the transaminases, the greater the
likelihood of EPL (p <0.05). Multivariate regression analysis
found that the use of IVIG was an independent risk factor for elevated
transaminase in RSA patients (OR, 0.374; 95% CI, 0.162-0.864; p
=0.021). Conclusion: Serum transaminase levels are significantly
correlated with RSA early pregnancy loss. Moreover, medication use is
significantly correlated with transaminase elevation in the first
trimester in RSA patients, especially IVIG.