Self-microemulsifying drug delivery systems of <i>Moringa oleifera</i> extract for enhanced dissolution of kaempferol and quercetin

Sermkaew, Namfa; Plyduang, Thipapun

doi:10.2478/acph-2020-0012

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…This indicated that QR-SME possesses a greater surface area, which may promote the rate of quercetin and resveratrol release. Based on particle dispersion, QR-SME presented a unimodal distribution with a very narrow PDI index range, which was lower than that of the resveratrol loading microemulsions [28]; we have previously reported this and confirmed the good dispersion properties of QR-SME. The lower PDI value (< 0.3) indicated the narrow size distribution of the formulation and, furthermore, presented the suitable stability ▶ Table 3 In vivo pharmacokinetic parameters of a self-microemulsifying formulation loaded with quercetin/resveratrol (QR-SME) following oral administration compared with an unformulated quercetin/resveratrol combination (QR suspension) and the combination of Q-SME and R-SME, which represents the SME containing only 40 mg/kg quercetin or resveratrol.…”

Section: Discussionsupporting

confidence: 65%

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

et al. 2020

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Both quercetin and resveratrol are promising plant-derived compounds with various well-described biological activities; however, they are categorized as having low aqueous solubility and labile natural compounds. The purpose of the present study was to propose a drug delivery system to enhance the oral bioavailability of combined quercetin and resveratrol. The suitable self-microemulsifying formulation containing quercetin together with resveratrol comprised 100 mg Capryol 90, 700 mg Cremophor EL, 200 mg Labrasol, 20 mg quercetin, and 20 mg resveratrol, which gave a particle size of 16.91 ± 0.08 nm and was stable under both intermediate and accelerated storage conditions for 12 months. The percentages of release for quercetin and resveratrol in the self-microemulsifying formulation were 75.88 ± 1.44 and 86.32 ± 2.32%, respectively, at 30 min. In rats, an in vivo pharmacokinetics study revealed that the area under the curve of the self-microemulsifying formulation containing quercetin and resveratrol increased approximately ninefold for quercetin and threefold for resveratrol compared with the unformulated compounds. Moreover, the self-microemulsifying formulation containing quercetin and resveratrol slightly enhanced the in vitro antioxidant and cytotoxic effects on AGS, Caco-2, and HT-29 cells. These findings demonstrate that the self-microemulsifying formulation containing quercetin and resveratrol could successfully enhance the oral bioavailability of the combination of quercetin and resveratrol without interfering with their biological activities. These results provide valuable information for more in-depth research into the utilization of combined quercetin and resveratrol.

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Section: Discussionsupporting

confidence: 65%

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

et al. 2020

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“…Tween 80 and PEG400 are common oral pharmaceutical excipients, and both have very wide oral safety windows. 43 Therefore, EO was selected as the oil phase, Tween 80 as the surfactant, and PEG400 as the cosurfactant.…”

Section: Results and Discussion Preparation And Characterization Of Omentioning

confidence: 99%

<p>Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma</p>

Cao¹,

Zhan²,

Wang³

et al. 2020

IJN

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“…e estimated absorption of Qu glucoside, the naturally occurring form of Qu, ranges from 3% to 17% in healthy individuals receiving 100 mg [36]. Some modified dosage forms of Qu have been developed to overcome these disadvantages, mainly including nanoparticles [37], microemulsions [38], and other drug carriers [39].…”

Section: Pharmacology and Bioavailability Of Quercetinmentioning

confidence: 99%

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

Deng

Fang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest morbidity and mortality globally. It causes a huge burden on families and caregivers and high costs for medicine and surgical interventions. Given expensive surgeries and failures of most conventional treatments, medical community tries to find a more cost-effective cure. Thus, attentions have been primarily focused on food or herbs. Quercetin (Qu) extracted from food, a flavonoid component, develops potentials of alternative or complementary medicine in atherosclerosis. Due to the wide range of health benefits, researchers have considered to apply Qu as a natural compound in therapy. This review is aimed to identify the antiatherosclerosis functions of Qu in treating ASCVD such as anti-inflammatory, antioxidant properties, effects on endothelium-dependent vasodilation, and blood lipid-lowering.

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Self-microemulsifying drug delivery systems of Moringa oleifera extract for enhanced dissolution of kaempferol and quercetin

Cited by 15 publications

References 21 publications

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System

<p>Development of an Orally Bioavailable Isoliquiritigenin Self-Nanoemulsifying Drug Delivery System to Effectively Treat Ovalbumin-Induced Asthma</p>

Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

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