Self nanoemulsifying drug delivery system (SNEDDS) of Rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation

Balakumar, K; Raghavan, Chellan Vijaya; selvan, Natarajan Tamil; prasad, Ranganathan Hari; Abdu, Siyad

doi:10.1016/j.colsurfb.2013.08.025

Cited by 270 publications

(145 citation statements)

References 30 publications

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“…Average zeta potential value of the droplets of nanoemulsion was -38.7 mV, as seen in Figure 7. The value is negative because of the presence of the free fatty acid as one of the component of olive oil and Tween 80 in SNEDDS formulation (Balakumar, et al, 2013). The value is considered optimum if more than ±30 mV (Singh and Liliard, 2009).…”

Section: Figure 6:-size and Size Distribution Of Nanoemulsionmentioning

confidence: 99%

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Wulandari¹,

Alverina²,

Martien³

2016

IJAR

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Section: Figure 6:-size and Size Distribution Of Nanoemulsionmentioning

confidence: 99%

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Wulandari¹,

Alverina²,

Martien³

2016

IJAR

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“…This hypothesis was believed to be attained chiefly, by lymphatic transport via Peyer's patches along the GI tract (Balakumara et al, 2013). Self-emulsifying drug delivery system is one among the lipid-based drug delivery systems that has been currently investigated for its advantages, providing a large interfacial area for partitioning the drug between oil and GI fluid (Jeevana et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics andin situsingle pass intestinal perfusion (SPIP) studies

2014

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Trans-resveratrol (t-RVT) is a potent antioxidant. By virtue of extensive pre-systemic metabolism and existence of enterohepatic recirculation, t-RVT bioavailability is almost zero. The current study aimed to develop self-nanoemulsifying drug delivery systems (SNEDDS) using long-chain triglycerides (LCTs) of t-RVT in an attempt to circumvent such obstacles. Equilibrium solubility studies indicated the choice of Lauroglycol FCC as lipid, and of Labrasol and Transcutol P as surfactants, for formulating the SNEDDS. Ternary phase diagrams were constructed to select the areas of nanoemulsions, and the amounts of lipid (X 1 ) and surfactant (X 2 ) as the critical factor variables. The SNEDDS were optimized using 3 2 central composite design (CCD) and the optimized formulation (OPT) located using overlay plot. The nanometer size range and high negative values of zeta potential depicted non-coalescent nature of the SNEDDS. Optimized formulation indicated marked improvement in drug release profile vis-à-vis pure drug. Cloud point determination and accelerated stability studies ascertained the stability of OPT. Augmentation in the values of K a (3.29-fold) and AUC (4.31-fold) indicated significant enhancement in the rate and extent of bioavailability by the OPT compared with pure drug. In situ perfusion (SPIP) studies in Wistar rats construed remarkable enhancement in the absorptivity and permeability parameters of SNEDDS vis-à-vis the pure drug. Successful establishment of level A of in vitro/in vivo correlation substantiated the judicious choice of the in vitro dissolution milieu for simulating the in vivo conditions. The present study, therefore, reports the successful development of SNEDDS with distinctly enhanced bioavailability of t-RVT. KeywordsBioavailability, central composite design, in situ single pass intestinal perfusion, pharmacokinetic study, self-nanoemulsifying drug-delivery system History

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“…Phase diagram studies help to understand phase behavior of the formed nanoemulsion (Balakumar et al, 2013). Diagrams were constructed to determine the self-nanoemulsifying area and to make a decision about an optimum concentration of oil, surfactant and co-surfactant for the development of liquid SNEDDS formulations.…”

Section: Resultsmentioning

confidence: 99%

“…After dilution, they create nanoscale size emulsion droplets. Decreasing droplet size increase surface area and improve the dissolution rates as well as bioavailability (Balakumar et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Budesonide self-nanoemulsion formulation as an oral drug delivery system: preparation, characterization and cytotoxicity studies

Mesut¹,

Sahin²,

Özsoy³

2017

Pressacademia

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Lipophilic drugs which are poorly water soluble need specific applications like lipid based delivery systems to increase their oral absorption across gastrointestinal tract. Selfnanoemulsifying drug delivery systems are Lipid Based Drug Delivery systems (SNEEDs) and are consists of an isotropic mixture of oil, surfactant(s) and co-surfactant. This drug delivery systems are prepared at room temperature with gentle stirring process without using any other component or heating process and become nanoemulsion form upon gentle agitation in aqueous phase. SNEDDs have many advantages such as they can be produced easily and they are affected less from other outside factors, its scaleup process is easy, unaffected by lipid digestion, carry and protect peptides which can be enzymatically hydrolyzed. The aim of this study was to increase solubility of Budesonide by using new Snedds formulation approach.

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Self nanoemulsifying drug delivery system (SNEDDS) of Rosuvastatin calcium: Design, formulation, bioavailability and pharmacokinetic evaluation

Cited by 270 publications

References 30 publications

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics andin situsingle pass intestinal perfusion (SPIP) studies

Budesonide self-nanoemulsion formulation as an oral drug delivery system: preparation, characterization and cytotoxicity studies

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