Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies

Li, Wanwen; Yi, Shaoling; Wang, Zhouhua; Chen, Si; Xin, Shuang; Xie, Jingwen; Zhao, Chunshun

doi:10.1016/j.ijpharm.2011.08.024

Cited by 87 publications

(42 citation statements)

References 32 publications

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“…However, they formulated in a narrow range of P40 (30-70%) and DGE (25-40%). It has been reported that the drug incorporated in the SNEDDS may occasionally have some effects on the self-emulsifying performance and/or emulsion droplet size (27). However, in this study, no significant difference was observed in self-emulsifying performance between the SNEDDS and NDP-loaded SNEDDS formulations.…”

Section: Construction Of Ternary Phase Diagramcontrasting

confidence: 74%

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System

et al. 2014

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ABSTRACT. Self-nanoemulsifying drug delivery system (SNEDDS) can be used to improve dissolution of poorly water-soluble drugs. The objective of this study was to prepare SNEDDS by using ternary phase diagram and investigate their spontaneous emulsifying property, dissolution of nifedipine (NDP), as well as the pharmacokinetic profile of selected SNEDDS formulation. The results showed that the composition of the SNEDDS was a great importance for the spontaneous emulsification. Based on ternary phase diagram, the region giving the SNEDDS with emulsion droplet size of less than 300 nm after diluting in aqueous medium was selected for further formulation. The small-angle X-ray scattering curves showed no sharp peak after dilution at different percentages of water, suggesting non-ordered structure. The system was found to be robust in different dilution volumes; the droplet size was in nanometer range. In vitro dissolution study showed remarkable increase in dissolution of NDP from SNEDDS formulations compared with NDP powders. The pharmacokinetic study of selected SNEDDS formulation in male Wistar rats revealed the improved maximum concentration and area under the curve. Our results proposed that the developed SNEDDS formations could be promising to improve the dissolution and oral bioavailability of NDP.

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Section: Construction Of Ternary Phase Diagramcontrasting

confidence: 74%

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System

et al. 2014

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“…The vehicles (oils, surfactants and co-surfactants) provided higher solubility of the herbal drugs were selected for constructing the phase diagram without drugs (blank phase diagram). Pseudo-ternary phase diagrams and ternary phase diagrams are used in the investigation of blank SEDDS which are shown in Figure 4 ( Li et al, 2011b;Zhang et al, 2012). The pseudo-ternary phase diagrams are constructed by titration of homogenous liquid mixtures of oil, surfactant and co-surfactant with water at room temperature (Djordjevic et al, 2004;Subramanian et al, 2004;Desai et al, 2012).…”

Section: Application Of Construction Of Phase Diagram In Herbal Medicinementioning

confidence: 99%

“…These values were then used to determine the boundaries of the micro/nanoemulsion regions corresponding to the selected optimum ratios of combination vehicles for developing SEDDS. In a current study of persimmon leaf extract (PLE) loaded SNEDDS, pseudo-ternary phase diagrams were constructed by Micro Plate Dilution (PDMPD) method, based on the water titration method, was a novel for phase diagram construction (Li et al, 2011b). In brief, the mixtures of oil, surfactant and co-surfactant at certain weight ratios were gradually diluted with water in a microtitre plate (96 wells, 350 ml volumes each).…”

Section: Application Of Construction Of Phase Diagram In Herbal Medicinementioning

confidence: 99%

Self-emulsifying drug delivery system and the applications in herbal drugs

Zhang

et al. 2013

Drug Delivery

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Herbal drugs have been used for thousands of years in the east and have had a recent resurgence in popularity among consumers in the west. However, most of herbal drug are poorly soluble and have hydrophobic properties and poor distribution, leading to reduced bioavailability and hence decreased treatment efficacy, requiring repeated administration or increased dose. In the past few decades, considerable attention has been focused on the development of self-emulsifying drug delivery system (SEDDS) for herbal drugs. SEDDS is isotropic and thermodynamically stable solutions consisting of oil, surfactant, co-surfactant and drug that can spontaneously form oil-in-water micro/nanoemulsion when mixed with water under gentle stirring. The formulation can be a viable alternative to classical formulations to take advantage of their lipophilic nature and to solve their problems of poor solubility, poor bioavailability, low oral absorption and instability. The mechanism of self-emulsification, solubility studies, construction of phase diagram, optimization and characterization of herbal drugs-loaded SEDDS formulation and in situ absorption evaluation of herbal drugs in rat intestine are presented in our article.

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“…[45; 64] Microemulsions with droplets size under 200 nm were considered acceptable according to Jain et al [68] . A smaller droplet size would bring forth a larger interfacial surface area for drug absorption; [69] therefore, a faster release rate could be achieved. [25; 34; 37; 70] PI value is a measure of the width of size distribution and ranges from 0 to 1.…”

Section: Physicochemical Properties Of Liquid Seddsmentioning

confidence: 99%

Design and Development of Self-Emulsifying Drug Delivery Systems Novel Cardioactive N-Acylhydrazone Compound

Zanchetta¹,

Chaud²,

Santana³

2016

IJNN

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In this study, the emphasis is placed on a strategy for enhancing the drug/carrier interaction for improved drug solubility, drug-loading capacity, self-emulsification and stability.Preliminary solubility of L294 was determined in various oils, surfactants and cosurfactants. A ternary phase diagram was constructed to identify the self-emulsifying region for the selected systems, using series concentrations of Labrafac PG, Labrasol and Transcutol HP. Self-emulsifying properties, particle size, polydispersibility, and zeta potential were studied after dilution of formulations in water.The results demonstrated the development of a self-emulsifying formulation of L294 in liquid form, which upon contact with aqueous media spontaneously forms a clear nanoemulsion having a small droplet size (around 100 nm). The zeta potential of the selected SEDDS formulation was between −11.09 and −20.50 with a viscosity around 40-60 cP. The optimum formulation consisted of a mixture of Labrafac PG, Labrasol and Transcutol HP.The L294 showed extremely low water solubility (0,006 mg.mL -1 ), and when formulated in SEDDS, its solubility increased over than 33,000 fold.This study demonstrate that SEDDS can be considered as a very good candidate to optimize the peroral administration of L294.

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Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies

Cited by 87 publications

References 32 publications

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System

Spontaneous Emulsification of Nifedipine-Loaded Self-Nanoemulsifying Drug Delivery System

Self-emulsifying drug delivery system and the applications in herbal drugs

Design and Development of Self-Emulsifying Drug Delivery Systems Novel Cardioactive N-Acylhydrazone Compound

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