Self-nanoemulsifying drug delivery systems (SNEDDS) for oral delivery of arteether: pharmacokinetics, toxicity and antimalarial activity in mice

Abstract

The nontoxic SNEDDS of arteether, improved arteether bioavailability and anti-malarial efficacy.

Integrin αvβ3 Receptor Overexpressing on Tumor-Targeted Positive MRI-Guided Chemotherapy

“…The distribution in the liver and spleen suggests that NDs could be rapidly uptaken through the reticuloendothelial system, and the targeting ability of RGD enhances tumor site accumulation, similar to the in vivo performance of many other nanomaterials. 61,66 The results were almost identical to those of in vivo MR imaging studies. The results also suggest that NDs tend to accumulate in tissues with high density of macrophages, which could be excreted from the body primarily through hepatobiliary clearance.…”

Development of a Self-Nanoemulsifying Drug Delivery System (Snedds) From an Insulin Complex With Modified Phosphatidylcholine and Mucoadhesive Polysaccharide Coating as a Potential None-Invasive Treatment for Diabetes

“…Currently self-nanoemulsifiable drug delivery systems SNEDDS have shown promising potential in the pharmaceutical industry for the administration of different drugs (Cavazos Garduño et al, 2014;Dwivedi et al, 2014). A nanoemulsion is a system composed of a continuous and a dispersed phase, in addition to a surfactant or emulsifier that helps to stabilize the system (Alizadeh-Sani et al, 2018).…”

Improved oral bioavailability of novel antithrombotic S002-333 via chitosan coated liposomes: a pharmacokinetic assessment

“…17,18 Few drugs that are successfully marketed as liposomal formulations include Sustiva® (efavirenz), Fortovase® (saquinavir), Norvir® (ritonavir), Lamprene® (clofazimine). 19,[25][26][27] The purpose of present study was to develop and optimize a liposomal formulation comprising S002-333 in order to improve its oral bioavailability. Liposomal delivery of the drug can change the pharmacokinetic behavior and bioavailability resulting in better delivery at the intended site of action.…”

“…24,25 A water-insoluble drug can be formulated as a lipid-based formulation when the drug's conventional formulation approaches do not enhance its oral bioavailability. 19,[25][26][27] The purpose of present study was to develop and optimize a liposomal formulation comprising S002-333 in order to improve its oral bioavailability. S002-333 loaded liposomes were prepared by ethanol injection method and characterized for various physicochemical parameters.…”