Self‐Optimizing Continuous Reactions in Supercritical Carbon Dioxide

Abstract

Vollautomatisch: Mit einer Kombination aus automatisiertem Flussreaktor, Online‐Analyse und Steuerungsalgorithmus (siehe schematischen Aufbau) gelingt die effiziente Optimierung von Reaktionen zu einem gegebenen Produkt ohne die Notwendigkeit eines Eingriffs durch den Menschen.

Automatic discovery and optimization of chemical processes

“…A similar approach has been followed in most systems reported to date, in which self-optimization has been implemented. These systems cover different areas of chemistry: polymerization reaction [13 ,14 ], heterogeneous catalytic processes [1,2,5], droplet formation [15,16] assembly of nanoparticles [17] and even multi-step syntheses [4,[18][19][20][21]. As we shall show below, this approach to automation is readily extendable to include chemoinformatics and design of experiments, using data exchange standards, such as OPC.…”

4. Technology overview/Overview of the devices

“…-In-house solutions: When a cheap and effective mixing of a biphasic reaction is needed, simple sand, silica gel or glass beads can efficiently do the job [7,8]. Foams are available in metal (titanium, nickel) or plastic (for example PTFE) with different pore sizes.…”

Using Carbon Dioxide as a Building Block in Continuous Flow Synthesis

“…Since the use of supercritical CO 2 (scCO 2 )a sareaction medium [15][16][17][18] andt ransformations of CO 2 into other C 1 compounds [19,20] have been expanded in the laboratory scale by introducing continuous flow systems,t his review will focus on the use of CO 2 as a building block in continuousflow. Since the use of supercritical CO 2 (scCO 2 )a sareaction medium [15][16][17][18] andt ransformations of CO 2 into other C 1 compounds [19,20] have been expanded in the laboratory scale by introducing continuous flow systems,t his review will focus on the use of CO 2 as a building block in continuousflow.…”