2024
DOI: 10.18388/pb.2021_521
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Self-organisation of early stress response in the biology of cancer

Jekaterina Erenpreisa,
Kristine Salmina,
Ninel M Vainshelbaum
et al.

Abstract: The early stress response by AP-1 (FOS/JUN), supported by upregulation of c-Myc and involved in cell-fate changes and adaptation to hostile environments, is increased in cancer. The review shows the biphasic character of this response with negative feed-back typically lasting a few hours as a feature of the genome regulation by self-organising criticality. It involves  rapid splitting of the pericentromeric heterochromatin clusters, opening of the active chromatin, and a massive transcription acceleration wave… Show more

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